Poxviruses:: Capturing cytokines and chemokines

被引：39

作者：

Alcamí, A ^{[1
]}

Symons, JA ^{[1
]}

Khanna, A ^{[1
]}

Smith, GL ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

SEMINARS IN VIROLOGY | 1998年 / 8卷 / 05期

基金：

英国惠康基金;

关键词：

cytokine; chemokine; receptor; poxvirus; virus pathogenesis;

D O I：

10.1006/smvy.1997.0143

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cytokines play a critical role in the regulation of immune responses and constitute important targets for virus immune evasion mechanisms. One strategy used by large DNA viruses is to encode proteins that mimic cytokines or cytokine receptors, which modulate the activity of cytokines during infection. Poxviruses encode a unique set of proteins that are secreted from the infected cell and function as soluble cytokine receptors or binding proteins and sequester tumor necrosis factor, interleukin-1 beta, or chemokines. Characterization of these poxvirus proteins is providing information on virus pathogenesis, the function of cytokines, and new strategies for immune modulation and therapeutic intervention, (C) 1998 Academic Press.

引用

页码：419 / 427

页数：9

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