Free IL-18 and IL-33 cytokines in chronic spontaneous urticaria

被引：72

作者：

Puxeddu, I. ^{[1
]}

Italiani, P. ^{[2
]}

Giungato, P. ^{[2
]}

Pratesi, F. ^{[1
]}

Panza, F. ^{[1
]}

Bartaloni, D. ^{[1
]}

Rocchi, V. ^{[1
]}

Del Corso, I. ^{[1
]}

Boraschi, D. ^{[2
]}

Migliorini, P. ^{[1
]}

机构：

[1] Univ Pisa, Dept Internal Med, Clin Immunol Unit, I-56100 Pisa, Italy

[2] CNR, Inst Biomed Technol, Immunobiol Unit, Pisa, Italy

来源：

CYTOKINE | 2013年 / 61卷 / 03期

关键词：

IL-18; IL-18BP; IL-33; Cytokine; Chronic urticaria; SERUM SKIN-TEST; INTERLEUKIN-18; DISEASES;

D O I：

10.1016/j.cyto.2013.01.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Overproduction of IL-18 has been described in chronic urticaria. To evaluate free IL-18 and IL-33 in chronic spontaneous urticaria (CSU). IL-18, its inhibitor IL-18BP, IL-33 and its soluble receptor ST2 (sST2) were measured (ELISA) in the sera of 73 CSU patients. Free IL-18 was calculated (law of mass action). Autologous serum skin test (ASST) was performed in all patients. Total IL-18, IL-18BP and free IL-18 serum levels were significantly higher in CSU than in controls. IL-18 and IL-18BP increased significantly in both ASST-positive and negative subgroups. Free IL-18 resulted significantly higher in the ASST-negative, but not in the ASST-positive subgroup. No differences in IL-33/sST2 levels were detected between CSU and controls. Increased levels of free IL-18 and IL-18BP, but not IL-33, was detected in CSU. Whether IL-18 up-regulation is a consequence of inflammation or one of the causes of the pathology needs to be addressed. (C) 2013 Published by Elsevier Ltd.

引用

页码：741 / 743

页数：3

共 15 条

[1]

IgE Mediated Autoallergy against Thyroid Peroxidase - A Novel Pathomechanism of Chronic Spontaneous Urticaria? [J].

Altrichter, Sabine ;

Peter, Hans-Juergen ;

Pisarevskaja, Dina ;

Metz, Martin ;

Martus, Peter ;

Maurer, Marcus .

PLOS ONE, 2011, 6 (04)

[2]

Boraschi D, 2006, EUR CYTOKINE NETW, V17, P224

[3]

CURRENT CONCEPTS - CHRONIC URTICARIA [J].

GREAVES, MW .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (26) :1767-1772

[4]

Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation [J].

Hayakawa, Hiroko ;

Hayakawa, Morisada ;

Kume, Akihiro ;

Tominaga, Shin-ichi .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (36) :26369-26380

[5]

EAACI/GA2LEN task force consensus report: the autologous serum skin test in urticaria [J].

Konstantinou, G. N. ;

Asero, R. ;

Maurer, M. ;

Sabroe, R. A. ;

Schmid-Grendelmeier, P. ;

Grattan, C. E. H. .

ALLERGY, 2009, 64 (09) :1256-1268

[6]

Autologous serum skin test response in chronic spontaneous urticaria and respiratory diseases and its relationship with serum interleukin-18 level [J].

Kurt, Emel ;

Aktas, Ayse ;

Aksu, Kurtulus ;

Keren, Metin ;

Dokumacioglu, Ali ;

Goss, Christopher H. ;

Alatas, Ozkan .

ARCHIVES OF DERMATOLOGICAL RESEARCH, 2011, 303 (09) :643-649

[7]

Serum and urinary levels of IL-18 and its inhibitor IL-18BP in systemic lupus erythematosus [J].

Migliorini, Paola ;

Anzilotti, Consuelo ;

Pratesi, Federico ;

Quattroni, Paola ;

Bargagna, Marco ;

Dinarello, Charles A. ;

Boraschi, Diana .

EUROPEAN CYTOKINE NETWORK, 2010, 21 (04) :264-271

[8]

Primary sources and immunological prerequisites for sST2 secretion in humans [J].

Mildner, Michael ;

Storka, Angela ;

Lichtenauer, Michael ;

Mlitz, Veronika ;

Ghannadan, Minoo ;

Hoetzenecker, Konrad ;

Nickl, Stefanie ;

Dome, Balazs ;

Tschachler, Erwin ;

Ankersmit, Hendrik Jan .

CARDIOVASCULAR RESEARCH, 2010, 87 (04) :769-777

[9]

A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18 [J].

Novick, D ;

Schwartsburd, B ;

Pinkus, R ;

Suissa, D ;

Belzer, I ;

Sthoeger, Z ;

Keane, WF ;

Chvatchko, Y ;

Kim, SH ;

Fantuzzi, G ;

Dinarello, CA ;

Rubinstein, M .

CYTOKINE, 2001, 14 (06) :334-342

[10]

Interleukin-33 biology with potential insights into human diseases [J].

Palmer, Gaby ;

Gabay, Cem .

NATURE REVIEWS RHEUMATOLOGY, 2011, 7 (06) :321-329

← 1 2 →