GABAergic transmission in temporal lobe epilepsy: The role of neurosteroids

被引：21

作者：

Joshi, Suchitra ^{[1
]}

Rajasekaran, Karthik ^{[1
]}

Kapur, Jaideep ^{[1
]}

机构：

[1] Univ Virginia, Hlth Sci Ctr, Dept Neurol, Charlottesville, VA 22908 USA

来源：

EXPERIMENTAL NEUROLOGY | 2013年 / 244卷

关键词：

Temporal lobe epilepsy; GABA-A receptors; Neurosteroids; Trafficking; Physiology; Pharmacology; GAMMA-AMINOBUTYRIC-ACID; DENTATE GRANULE CELLS; ENHANCED ANTICONVULSANT ACTIVITY; SYNCHRONIZED HIPPOCAMPAL BURSTS; RECEPTOR-MEDIATED INHIBITION; CULTURED MAMMALIAN NEURONS; ACTIVE GABA(A) RECEPTORS; PAIRED-PULSE DEPRESSION; GUINEA-PIG HIPPOCAMPUS; SUBUNIT KNOCKOUT MICE;

D O I：

10.1016/j.expneurol.2011.10.028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Modification of GABAergic inhibition is an intensely investigated hypothesis guiding research into mechanisms underlying temporal lobe epilepsy (TLE). Seizures can be initiated by blocking gamma amino butyric acid type A (GABAA receptors, GABARs), which mediate fast synaptic inhibition in the brain, and controlled by drugs that enhance their function. Derivatives of steroid hormones called neurosteroids are natural substances that physiologically enhance GABAR function and suppress seizures. GABAR structure, function, expression, assembly, and pharmacological properties are changed in the hippocampus of epileptic animals. These alterations render GABARs less sensitive to neurosteroid modulation, which may contribute to seizure susceptibility. Plasticity of GABARs could play a role in periodic exacerbation of seizures experienced by women with epilepsy, commonly referred to as catamenial epilepsy. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：36 / 42

页数：7

共 143 条

[1]

Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis [J].