A new reference implementation of the PSICQUIC web service

被引:68
作者
del-Toro, Noemi [1 ]
Dumousseau, Marine [1 ]
Orchard, Sandra [1 ]
Jimenez, Rafael C. [1 ]
Galeota, Eugenia [2 ]
Launay, Guillaume [3 ]
Goll, Johannes [4 ]
Breuer, Karin [5 ]
Ono, Keiichiro [6 ,7 ]
Salwinski, Lukasz [8 ]
Hermjakob, Henning [1 ]
机构
[1] EMBL European Bioinformat Inst, Cambridge CB10 1SD, England
[2] Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy
[3] Univ Lyon 1, Inst Biol & Chim Prot, CNRS UMR5086, F-69367 Lyon, France
[4] J Craig Venter Inst, Rockville, MD USA
[5] Simon Fraser Univ, Dept Mol Biol & Biochem, Burnaby, BC V5A 1S6, Canada
[6] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA
[7] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
[8] Univ Calif Los Angeles, Dept Energy Inst Genom & Prote, Los Angeles, CA 90095 USA
基金
美国国家卫生研究院; 加拿大健康研究院;
关键词
CYTOSCAPE;
D O I
10.1093/nar/gkt392
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The Proteomics Standard Initiative Common QUery InterfaCe (PSICQUIC) specification was created by the Human Proteome Organization Proteomics Standards Initiative (HUPO-PSI) to enable computational access to molecular-interaction data resources by means of a standard Web Service and query language. Currently providing >150 million binary interaction evidences from 28 servers globally, the PSICQUIC interface allows the concurrent search of multiple molecular-interaction information resources using a single query. Here, we present an extension of the PSICQUIC specification (version 1.3), which has been released to be compliant with the enhanced standards in molecular interactions. The new release also includes a new reference implementation of the PSICQUIC server available to the data providers. It offers augmented web service capabilities and improves the user experience. PSICQUIC has been running for almost 5 years, with a user base growing from only 4 data providers to 28 (April 2013) allowing access to 151 310 109 binary interactions. The power of this web service is shown in PSICQUIC View web application, an example of how to simultaneously query, browse and download results from the different PSICQUIC servers. This application is free and open to all users with no login requirement (http://www.ebi.ac.uk/Tools/webservices/psicquic/view/main.xhtml).
引用
收藏
页码:W601 / W606
页数:6
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