Phasic alterations in dopamine and serotonin release in striatum and prefrontal cortex in response to cocaine predictive cues in behaving rhesus macaques

被引:26
作者
Bradberry, CW
Rubino, SR
机构
[1] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15260 USA
[2] Univ Pittsburgh, Ctr Neural Basis Cognit, Pittsburgh, PA 15260 USA
[3] Yale Univ, Dept Neurol, New Haven, CT 06520 USA
[4] VA, West Haven, CT USA
关键词
cingulate; orbitofrontal; cocaine; dopamine; self-administration; serotonin; primate;
D O I
10.1038/sj.npp.1300386
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The ability of environmental cues associated with cocaine availability to cause relapse may result from conditioned activation of dopamine (DA) release. We examined this hypothesis in macaque monkeys by conducting microdialysis studies in animals during exposure to a cocaine predictive compound cue. In addition to studying DA release in mesolimbic and sensorimotor striatum, both DA and serotonin levels were determined in the prefrontal cortex (medial orbitofrontal and anterior cingulate). The compound cue employed visual, auditory, and olfactory components, and was salient to the animals as demonstrated by anticipatory lever pressing in the absence of cocaine. During a 10-min period of exposure prior to cocaine availability, there was no significant increase in striatal or cortical DA. The addition of a DA uptake inhibitor to the striatal perfusate to reduce the potential interference of neuronal uptake did not alter the results. In contrast to the lack of any change in striatal DA, a significant decrease in extracellular serotonin in the prefrontal cortex during the 10 min of cue exposure was observed.
引用
收藏
页码:676 / 685
页数:10
相关论文
共 69 条
[1]   NMDA antagonist effects on striatal dopamine release: Microdialysis studies in awake monkeys [J].
Adams, BW ;
Bradberry, CW ;
Moghaddam, B .
SYNAPSE, 2002, 43 (01) :12-18
[2]  
ARNSTEN AFT, 1984, BRAIN RES, V306, P9, DOI 10.1016/0006-8993(84)90351-2
[3]   SOURCES OF RELAPSE AFTER EXTINCTION IN PAVLOVIAN AND INSTRUMENTAL LEARNING [J].
BOUTON, ME ;
SWARTZENTRUBER, D .
CLINICAL PSYCHOLOGY REVIEW, 1991, 11 (02) :123-140
[4]   COCAINE INCREASES EXTRACELLULAR DOPAMINE IN RAT NUCLEUS ACCUMBENS AND VENTRAL TEGMENTAL AREA AS SHOWN BY INVIVO MICRODIALYSIS [J].
BRADBERRY, CW ;
ROTH, RH .
NEUROSCIENCE LETTERS, 1989, 103 (01) :97-102
[5]   COCAINE AND COCAETHYLENE - MICRODIALYSIS COMPARISON OF BRAIN DRUG LEVELS AND EFFECTS ON DOPAMINE AND SEROTONIN [J].
BRADBERRY, CW ;
NOBILETTI, JB ;
ELSWORTH, JD ;
MURPHY, B ;
JATLOW, P ;
ROTH, RH .
JOURNAL OF NEUROCHEMISTRY, 1993, 60 (04) :1429-1435
[6]   Impact of self-administered cocaine and cocaine cues on extracellular dopamine in mesolimbic and sensorimotor striatum in rhesus monkeys [J].
Bradberry, CW ;
Barrett-Larimore, RL ;
Jatlow, P ;
Rubino, SR .
JOURNAL OF NEUROSCIENCE, 2000, 20 (10) :3874-3883
[7]   Acute and chronic dopamine dynamics in a nonhuman primate model of recreational cocaine use [J].
Bradberry, CW .
JOURNAL OF NEUROSCIENCE, 2000, 20 (18) :7109-7115
[8]   Acute effects of cocaine on human brain activity and emotion [J].
Breiter, HC ;
Gollub, RL ;
Weisskoff, RM ;
Kennedy, DN ;
Makris, N ;
Berke, JD ;
Goodman, JM ;
Kantor, HL ;
Gastfriend, DR ;
Riorden, JP ;
Mathew, RT ;
Rosen, BR ;
Hyman, SE .
NEURON, 1997, 19 (03) :591-611
[9]   COCAINE-INDUCED CONDITIONED LOCOMOTION - ABSENCE OF ASSOCIATED INCREASES IN DOPAMINE RELEASE [J].
BROWN, EE ;
FIBIGER, HC .
NEUROSCIENCE, 1992, 48 (03) :621-629
[10]   EFFERENT CONNECTIONS OF THE MEDIAL PREFRONTAL CORTEX IN THE RABBIT [J].
BUCHANAN, SL ;
THOMPSON, RH ;
MAXWELL, BL ;
POWELL, DA .
EXPERIMENTAL BRAIN RESEARCH, 1994, 100 (03) :469-483