Long-term Effects of the Oral Adsorbent, AST-120, in Patients with Chronic Renal Failure

被引：30

作者：

Maeda, K. ^{[1
]}

Hamada, C. ^{[2
]}

Hayashi, T. ^{[2
]}

Shou, I. ^{[2
]}

Wakabayashi, M. ^{[2
]}

Fukui, M. ^{[2
]}

Horikoshi, S. ^{[2
]}

Tomino, Y. ^{[2
]}

机构：

[1] Juntendo Univ, Nerima Hosp, Div Nephrol, Dept Internal Med,Nerima Ku, Tokyo 1778521, Japan

[2] Juntendo Univ, Sch Med, Dept Internal Med, Div Nephrol, Tokyo 113, Japan

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2009年 / 37卷 / 01期

关键词：

ORAL ADSORBENT; AST-120; CHRONIC RENAL FAILURE; RECIPROCAL SERUM CREATININE; LONG-TERM USE; PROGRESSION; INJURY;

D O I：

10.1177/147323000903700125

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

The oral adsorbent AST-120 has been widely used in Japan to delay the initiation of dialysis therapy in patients with chronic renal failure. This study evaluated the long-term effects of AST-120 in patients with chronic renal failure who had not previously undergone dialysis. One hundred out-patients were prospectively enrolled and prescribed 6 g/day oral AST-120 for >= 1 year. The clinical effectiveness of AST-120 was evaluated by comparing changes in the slope of the reciprocal serum creatinine-time plot (1/sCr slope) before and after AST-120 administration. The 1/sCr slope improved significantly after ! 1 year of AST-120 treatment and greatest improvement was observed in patients with the longest AST-120 administration period (> 30 months). The results suggest that long-term treatment with AST-120 may be beneficial for chronic renal failure patients in the pre-dialysis stage.

引用

页码：205 / 213

页数：9

共 11 条

[1]

[Anonymous], KIDNEY INT S

[2]

Goto Yasuo, 2001, Journal of the Japan Diabetes Society, V44, P377

[3]

Effects of oral adsorbent AST-120 (Kremezin®) on renal function and glomerular injury in early-stage renal failure of subtotal nephrectomized rats [J].

Kobayashi, N ;

Maeda, A ;

Horikoshi, S ;

Shirato, I ;

Tomino, Y ;

Ise, M .

NEPHRON, 2002, 91 (03) :480-485

[4]

Uraemic toxins induce proximal tubular injury via organic anion transporter 1-mediated uptake [J].

Motojima, M ;

Hosokawa, A ;

Yamato, H ;

Muraki, T ;

Yoshioka, T .

BRITISH JOURNAL OF PHARMACOLOGY, 2002, 135 (02) :555-563

[5]

NIWA T, 1994, J LAB CLIN MED, V124, P96

[6]

*PAT REG COMM, 2006, ANN REP JAP SOC DIAL

[7]

Effect of combined treatment of oral sorbent with protein-restricted diet on change of reciprocal creatinine slope in patients with CRF [J].

Sanaka, T ;

Fujimoto, K ;

Niwayama, J ;

Nishimura, H ;

Naito, T ;

Higuchi, C ;

Akizawa, T ;

Koide, K ;

Koshikawa, S .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2003, 41 (03) :S35-S37

[8]

Clinical analysis of renoprotective responding patients administrated with oral adsorbent in chronic renal failure secondary to chronic glomerulonephritis [J].

Sanaka, T ;

Akizawa, T ;

Koide, K ;

Koshikawa, S .

THERAPEUTIC APHERESIS AND DIALYSIS, 2003, 7 (02) :269-278

[9]

Prospective randomized study evaluating the efficacy of the spherical adsorptive carbon AST-120 in chronic kidney disease patients with moderate decrease in renal function [J].

Shoji, Tatsuya ;

Wada, Akira ;

Inoue, Kazunori ;

Hayashi, Daisuke ;

Tomida, Kodo ;

Furumatsu, Yoshiyuki ;

Kaneko, Tetsuya ;

Okada, Noriyuki ;

Fukuhara, Yoshifumi ;

Imai, Enyu ;

Tsubakihara, Yoshiharu .

NEPHRON CLINICAL PRACTICE, 2007, 105 (03) :99-107

[10]

Therapeutic effects of long-term administration of an oral adsorbent in patients with chronic renal failure: two-year study [J].

Takahashi, N ;

Kawaguchi, T ;

Suzuki, T .

INTERNATIONAL JOURNAL OF UROLOGY, 2005, 12 (01) :7-11

← 1 2 →