Linkages between chemical contaminants and tumors in benthic Great Lakes

被引:69
作者
Baumann, PC
Smith, IR
Metcalfe, CD
机构
[1] ONTARIO MINIST ENVIRONM & ENERGY, TORONTO, ON M4V 1M2, CANADA
[2] TRENT UNIV, PETERBOROUGH, ON K9J 7B8, CANADA
关键词
brown bullheads; white suckers; papilloma; neoplasms; Great Lakes;
D O I
10.1016/S0380-1330(96)70946-2
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Cutaneous papilloma have been observed at high prevalences in populations of brown bullheads (Ameiurus nebulosus) and white suckers (Catostomus commersoni) distributed throughout the Great Lakes, with no clear-cut delineation between prevalences in fish populations from industrialized sites in comparison to more pristine sites. However bullhead papilloma prevalences greater than 20% were never observed at pristine reference sites, while high prevalences of slicker papilloma (> 20%) were only observed in populations from the lower Great Lakes. It is probable that there is a viral etiology for papilloma affecting bullheads and suckers, although chemical contaminants map influence the development of these neoplasms through some mechanism. Hepatic neoplasms of both cholangiocytic and hepatocytic origin hale been observed at relatively high prevalences in Great Lakes populations of brown bullheads and white suckers. Prevalences of total hepatic neoplasms of > 9% in bullheads and > 3% in suckers Mere usually only observed in populations from industrialized areas of the Great Lakes. However, relatively high prevalences of hepatic neoplasms were also observed in suckers and bullheads from pristine areas where there is a preponderance of older fish in the population. Iii the case of both bullheads and suckers, high prevalences of hepatic neoplasms appear to be associated with severe biliary disease (e.g. cholangiofibrosis, cholangiohepatitis). It is highly probable that the etiology of hepatic cancers in bullheads and suckers from the Great Lakes is associated with exposure to chemical contaminants, and in some areas, specifically with exposure to polynuclear aromatic hydrocarbons. However, other chemical contaminants may indirectly influence hepatic tumor rates by increasing the severity of biliary disease in fish from contaminated areas. Overall, cutaneous papilloma prevalences above approximately 25% and hepatic neoplasm prevalences above approximately 5% in these species should be interpreted as an indicator of environmental degradation in the area where fish were surveyed.
引用
收藏
页码:131 / 152
页数:22
相关论文
共 72 条
[1]   TUMOUR FORMATION IN PLATYFISH-SWORDTAIL HYBRIDS AS A PROBLEM OF GENE REGULATION [J].
ANDERS, F .
EXPERIENTIA, 1967, 23 (01) :1-&
[2]  
Anderson P., 1990, AM FISH SOC S, V8, P38
[3]   IDENTIFICATION OF POTENTIAL FISH CARCINOGENS IN SEDIMENT FROM HAMILTON HARBOR, ONTARIO, CANADA [J].
BALCH, GC ;
METCALFE, CD ;
HUESTIS, SY .
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 1995, 14 (01) :79-91
[4]  
Balch GC, 1995, ENVIR SCI R, V50, P249
[5]  
Baumann Paul C., 1992, Journal of Aquatic Ecosystem Health, V1, P135, DOI 10.1007/BF00044045
[6]   DECLINE IN LIVER NEOPLASMS IN WILD BROWN BULLHEAD CATFISH AFTER COKING PLANT CLOSES AND ENVIRONMENTAL PAHS PLUMMET [J].
BAUMANN, PC ;
HARSHBARGER, JC .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1995, 103 (02) :168-170
[7]   TUMOR FREQUENCIES IN WALLEYE (STIZOSTEDION-VITREUM) AND BROWN BULLHEAD (ICTALURUS-NEBULOSUS) AND SEDIMENT CONTAMINANTS IN TRIBUTARIES OF THE LAURENTIAN GREAT-LAKES [J].
BAUMANN, PC ;
MAC, MJ ;
SMITH, SB ;
HARSHBARGER, JC .
CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES, 1991, 48 (09) :1804-1810
[8]   THE STATUS OF SELECTED ORGANICS IN THE LAURENTIAN GREAT-LAKES - AN OVERVIEW OF DDT, PCBS, DIOXINS, FURANS, AND AROMATIC-HYDROCARBONS [J].
BAUMANN, PC ;
WHITTLE, DM .
AQUATIC TOXICOLOGY, 1988, 11 (3-4) :241-257
[9]   RELATIONSHIP BETWEEN LIVER-TUMORS AND AGE IN BROWN BULLHEAD POPULATIONS FROM 2 LAKE ERIE TRIBUTARIES [J].
BAUMANN, PC ;
HARSHBARGER, JC ;
HARTMAN, KJ .
SCIENCE OF THE TOTAL ENVIRONMENT, 1990, 94 (1-2) :71-87
[10]  
BAUMANN PC, 1982, POLYNUCLEAR AROMATIC, P93