Atrophy of the substantia innominata on magnetic resonance imaging and response to donepezil treatment in Alzheimer's disease

被引：25

作者：

Hanyu, H ^{[1
]}

Tanaka, Y

Sakurai, H

Takasaki, M

Abe, K

机构：

[1] Tokyo Med Univ, Dept Geriatr Med, Tokyo 1600023, Japan

[2] Tokyo Med Univ, Dept Radiol, Tokyo 1600023, Japan

来源：

NEUROSCIENCE LETTERS | 2002年 / 319卷 / 01期

关键词：

Alzheimer's disease; magnetic resonance imaging; substantia innominata; cholinergic neuron; donepezil; responders;

D O I：

10.1016/S0304-3940(01)02507-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Atrophy of the substantia innominata on magnetic resonance imaging (MRI), reflecting degeneration of cholinergic neurons in the nucleus basalis of Meynert, may be an in vivo marker of cholinergic damage. We attempted to investigate whether the MRI features of the substantia innominata predict response to donepezil treatment in Alzheimer's patients. The thickness of the substantia innominata was measured on the coronal T2-weighted MRI th rough the anterior commissure. Seventy-two patients treated with donepezil were divided into the two groups (responders and non-responders) based on changes in Mini-Mental State Examination (MMSE) scores from baseline to study endpoint. Atrophy of the substantia innominata was more pronounced in responders than non-responders. There was a significant inverse correlation between thickness of the substantia innominata and MMSE changes. MRI analysis of the substantia innominata may be a simple and practical method for the selection of possible treatment responders. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：33 / 36

页数：4

共 21 条

[1] THE CHOLINERGIC HYPOTHESIS OF GERIATRIC MEMORY DYSFUNCTION [J].