Effects of Saccharomyces boulardii on cytokine secretion from intraepithelial lymphocytes infected by Escherichia coli and Candida albicans

被引：36

作者：

Fidan, Isil ^{[1
]}

Kalkanci, Ayse ^{[1
]}

Yesilyurt, Emine ^{[1
]}

Yalcin, Burce ^{[1
]}

Erdal, Berna ^{[1
]}

Kustimur, Semra ^{[1
]}

Imir, Turgut ^{[1
]}

机构：

[1] Gazi Univ, Dept Med Microbiol, Fac Med, TR-06500 Ankara, Turkey

来源：

MYCOSES | 2009年 / 52卷 / 01期

关键词：

Saccharomyces boulardii; probiotics; cytokines; BLOOD MONONUCLEAR-CELLS; DENDRITIC CELLS; MICE; EXPRESSION;

D O I：

10.1111/j.1439-0507.2008.01545.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Saccharomyces boulardii (S. boulardii) is a probiotic and used in the prevention or treatment of diarrhoea. Saccharomyces boulardii has many mechanisms to protect the host against diarrhoeal pathogens. It might modulate the immune system. In this study, the influence of S. boulardii on the secretion of cytokines from intraepithelial lymphocytes (IELs) infected with Escherichia coli (E. coli) and Candida albicans (C. albicans) was investigated in vitro. Cytokine levels were determined by enzyme-linked immunosorbent assay. The secretion of proinflammatory cytokines such as interleukin (IL)-1 beta was decreased in the infected IELs incubated with S. boulardii, but different from it, anti-inflammatory cytokine levels such as IL-4 and IL-10, however, were found to be higher. These findings demonstrated that S. boulardii may have protective effects against diarrhoeal pathogens by reducing the proinflammatory response.

引用

页码：29 / 34

页数：6

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