Irregularities in the Effect of Potassium Phosphate in Ynamide Synthesis

被引：68

作者：

Dooleweerdt, Karin ^{[1
,2
,3
]}

Birkedal, Henrik ^{[1
,2
]}

Ruhland, Thomas ^{[3
]}

Skrydstrup, Troels ^{[1
,2
]}

机构：

[1] Aarhus Univ, Dept Chem, DK-8000 Aarhus C, Denmark

[2] Aarhus Univ, Interdisciplinary Nanosci Ctr, DK-8000 Aarhus C, Denmark

[3] H Lundbeck & Co AS, Dept Med Chem & Support, DK-2400 Copenhagen, Denmark

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 23期

基金：

新加坡国家研究基金会;

关键词：

D O I：

10.1021/jo801935b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The yields of ynamides using Hsung's second generation protocol depend substantially on the quality of K3PO4. of K3PO4 from different suppliers were investigated by various techniques, revealing that the use Of pure and anhydrous K3PO4 provides higher ynamide yields in comparison to samples contaminated with hydrates (K3PO4 center dot 1.5H(2)O and K3PO4 center dot 7H(2)O). With high quality K3PO4, a number of ynamides were synthesized in yields of 52-91%. In addition. we report that ynamides can undergo regioselective hydroamination with carbamates.

引用

页码：9447 / 9450

页数：4

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