Immunostimulating effect of growth hormone: In-vivo administration of growth hormone in rainbow trout enhances resistance to Vibrio anguillarum infection

被引：23

作者：

Sakai, M ^{[1
]}

Kajita, Y ^{[1
]}

Kobayashi, M ^{[1
]}

Kawauchi, H ^{[1
]}

机构：

[1] KITASATO UNIV, SCH FISHERIES SCI, SANRIKU, IWATE 10201, JAPAN

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 1997年 / 57卷 / 1-2期

关键词：

growth hormone; rainbow trout; Vibrio anguillarum;

D O I：

10.1016/S0165-2427(96)05771-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In-vivo administration of purified (nGH) and recombinant (rGH) chum salmon, Oncorhynchus keta, growth hormone enhanced the survival of rainbow trout, O. mykiss, against virulent Vibrio anguillarum. Macrophages obtained from rainbow trout that were treated in vivo with either GH preparation showed enhanced stimulation of the chemiluminescent responses induced by opsonized V. anguillarum cells and increased phagocytic activities. However, the serum bactericidal activity against V. anguillarum was not enhanced in fish injected with nGH or rGH. These findings show that in-vivo administration of either GH preparation can effectively prime macrophages and increase the resistance to V. anguillarum in rainbow trout. (C) 1997 Elsevier Science B.V.

引用

页码：147 / 152

页数：6

共 19 条

[1]

AUSTIN B, 1993, BACTERIAL FISH PATHO, P1

[2]

Berczi I, 1987, HORMONES IMMUNITY, P145

[3] INVIVO ADMINISTRATION OF RECOMBINANT GROWTH-HORMONE OR GAMMA-INTERFERON ACTIVATES MACROPHAGES - ENHANCED RESISTANCE TO EXPERIMENTAL SALMONELLA-TYPHIMURIUM INFECTION IS CORRELATED WITH GENERATION OF REACTIVE OXYGEN INTERMEDIATES [J].

EDWARDS, CK ;

GHIASUDDIN, SM ;

YUNGER, LM ;

LORENCE, RM ;

ARKINS, S ;

DANTZER, R ;

KELLEY, KW .

INFECTION AND IMMUNITY, 1992, 60 (06) :2514-2521

[4] THE MACROPHAGE-ACTIVATING PROPERTIES OF GROWTH-HORMONE [J].

EDWARDS, CK ;

ARKINS, S ;

YUNGER, LM ;

BLUM, A ;

DANTZER, R ;

KELLEY, KW .

CELLULAR AND MOLECULAR NEUROBIOLOGY, 1992, 12 (05) :499-510

[5] THE PITUITARY-GLAND IS REQUIRED FOR PROTECTION AGAINST LETHAL EFFECTS OF SALMONELLA-TYPHIMURIUM [J].

EDWARDS, CK ;

YUNGER, LM ;

LORENCE, RM ;

DANTZER, R ;

KELLEY, KW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (06) :2274-2277

[6] A NEWLY DEFINED PROPERTY OF SOMATOTROPIN - PRIMING OF MACROPHAGES FOR PRODUCTION OF SUPEROXIDE ANION [J].

EDWARDS, CK ;

GHIASUDDIN, SM ;

SCHEPPER, JM ;

YUNGER, LM ;

KELLEY, KW .

SCIENCE, 1988, 239 (4841) :769-771

[7]

GALA RR, 1991, P SOC EXP BIOL MED, V198, P513

[8]

Iida T., 1983, Fish Pathology, V18, P77

[9]

Kajita Y., 1992, Fish & Shellfish Immunology, V2, P155, DOI 10.1016/S1050-4648(05)80044-0

[10] ISOLATION AND CHARACTERIZATION OF CHUM SALMON GROWTH-HORMONE [J].

KAWAUCHI, H ;

MORIYAMA, S ;

YASUDA, A ;

YAMAGUCHI, K ;

SHIRAHATA, K ;

KUBOTA, J ;

HIRANO, T .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1986, 244 (02) :542-552

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