Vibrational resonance in a time-delayed genetic toggle switch

被引：53

作者：

Daza, Alvar ^{[1
]}

Wagemakers, Alexandre ^{[1
]}

Rajasekar, Shanmuganathan ^{[2
]}

Sanjuan, Miguel A. F. ^{[1
]}

机构：

[1] Univ Rey Juan Carlos, Dept Fis, Nonlinear Dynam Chaos & Complex Syst Grp, Madrid 28933, Spain

[2] Bharathidasan Univ, Sch Phys, Tiruchirappalli 620024, Tamil Nadu, India

来源：

COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION | 2013年 / 18卷 / 02期

关键词：

Genetic toggle switch; Vibrational resonance; STOCHASTIC RESONANCE; OSCILLATIONS;

D O I：

10.1016/j.cnsns.2012.07.010

中图分类号：

O29 [应用数学];

学科分类号：

070104 [应用数学];

摘要：

Biological oscillators can respond in a surprising way when they are perturbed by two external periodic forcing signals of very different frequencies. The response of the system to a low-frequency signal can be enhanced or depressed when a high-frequency signal is acting. This is what is known as vibrational resonance (VR). Here we study this phenomenon in a simple time-delayed genetic toggle switch, which is a synthetic gene-regulatory network. We have found out how the low-frequency signal changes the range of the response, while the high-frequency signal influences the amplitude at which the resonance occurs. The delay of the toggle switch has also a strong effect on the resonance since it can also induce autonomous oscillations. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：411 / 416

页数：6

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