CoPub: a literature-based keyword enrichment tool for microarray data analysis

被引：58

作者：

Frijters, Raoul ^{[2
]}

Heupers, Bart ^{[3
]}

van Beek, Pieter ^{[3
]}

Bouwhuis, Maurice ^{[3
]}

van Schaik, Rene ^{[1
]}

de Vlieg, Jacob ^{[1
,2
]}

Polman, Jan ^{[1
]}

Alkema, Wynand ^{[1
]}

机构：

[1] Schering Plough Corp, Organon, Dept Mol Design & Informat, Oss, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, NCMLS, CDD, NL-6525 ED Nijmegen, Netherlands

[3] SARA Comp & Network Serv, Amsterdam, Netherlands

来源：

NUCLEIC ACIDS RESEARCH | 2008年 / 36卷

关键词：

D O I：

10.1093/nar/gkn215

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Medline is a rich information source, from which links between genes and keywords describing biological processes, pathways, drugs, pathologies and diseases can be extracted. We developed a publicly available tool called CoPub that uses the information in the Medline database for the biological interpretation of microarray data. CoPub allows batch input of multiple human, mouse or rat genes and produces lists of keywords from several biomedical thesauri that are significantly correlated with the set of input genes. These lists link to Medline abstracts in which the co-occurring input genes and correlated keywords are highlighted. Furthermore, CoPub can graphically visualize differentially expressed genes and over-represented keywords in a network, providing detailed insight in the relationships between genes and keywords, and revealing the most influential genes as highly connected hubs. CoPub is freely accessible at http://services.nbic.nl/cgi-bin/copub/CoPub.pl.

引用

页码：W406 / W410

页数：5

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