Pesticides and Parkinson's disease

被引：158

作者：

Le Couteur, DG ^{[1
]}

McLean, AJ

Taylor, MC

Woodham, BL

Board, PG

机构：

[1] Univ Sydney, Canberra Hosp, Canberra Clin Sch, Canberra, ACT 2605, Australia

[2] Australian Natl Univ, John Curtin Sch Med Res, Mol Genet Grp, Canberra, ACT 2601, Australia

[3] Australian Natl Univ, John Curtin Sch Med Res, Div Neurosci, Canberra, ACT 2601, Australia

来源：

BIOMEDICINE & PHARMACOTHERAPY | 1999年 / 53卷 / 03期

基金：

英国医学研究理事会;

关键词：

aging; Parkinson's disease; pesticide;

D O I：

10.1016/S0753-3322(99)80077-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Epidemiological studies and case reports provide evidence for an association between Parkinson's disease and past exposure to pesticides. Susceptibility to the effects of pesticides and other putative neurotoxins depends on variability in xenobiotic metabolism possibly generated by genetic polymorphisms, aging and variation in exposure to environmental agents including pesticides. The simplest mechanistic hypothesis for the association of pesticides with Parkinson's disease is that pesticides or their metabolites are directly toxic to mitochondria, although modulation of xenobiotic metabolism by pesticides provides an adjunct or alternative hypothesis. (C) 1999 Elsevier, Paris.

引用

页码：122 / 130

页数：9

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