Diarylheptanoids with free radical scavenging and hepatoprotective activity in vitro from Curcuma longa

被引：99

作者：

Song, EK

Cho, H

Kim, JS

Kim, NY

An, NH

Kim, JA

Lee, SH

Kim, YC ^{[1
]}

机构：

[1] Wonkwang Univ, MRRC, Iksan 570749, South Korea

[2] Wonkwang Univ, Coll Pharm, Iksan 570749, South Korea

[3] Yeungnam Univ, Coll Pharm, Kyongsan 712749, South Korea

来源：

PLANTA MEDICA | 2001年 / 67卷 / 09期

关键词：

D O I：

10.1055/s-2001-18860

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Assay-guided fractionation of the EtOAc soluble fraction of the rhizomes of Curcuma longa furnished three DPPH free radical scavenging diarylheptanoids, curcumin (1), demethoxy-curcumin (2), and bisdemethoxycurcumin (3). Compounds 1-3 showed the DPPH radical scavenging effects with IC50 values of 2.8, 39.2, 308.7 muM, respectively. L-Ascorbic acid and resveratrol as positive controls exhibited IC50 values of 22.5 and 25.0 muM, respectively. Compounds 1-3 showed significant hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC50 values of 1-3 are 86.9, 70.7, and 50.2 muM, respectively. Silybin (EC50 = 69.0 muM) and silychristin (EC50 = 82.7 muM) were used as positive controls.

引用

页码：876 / 877

页数：2

共 9 条

[1]

BENOIT GG, 1997, OXIDATIVE STRESS, V53, P423

[2]

STUDIES ON THE ACTIVITY OF BEPRIDIL AS A SCAVENGER OF FREE-RADICALS [J].