Silica-coated super paramagnetic iron oxide nanoparticles (SPION) as biocompatible contrast agent in biomedical photoacoustics

被引：96

作者：

Alwi, Rudolf ^{[1
]}

Telenkov, Sergey ^{[1
]}

Mandelis, Andreas ^{[1
]}

Leshuk, Timothy ^{[2
]}

Gu, Frank ^{[2
]}

Oladepo, Sulayman ^{[3
]}

Michaelian, Kirk ^{[3
]}

机构：

[1] Univ Toronto, Ctr Adv Diffus Wave Technol CADIFT, Dept Mech & Ind Engn, Toronto, ON M5S 3G8, Canada

[2] Univ Waterloo, Dept Chem Engn, Waterloo, ON N2L 3G1, Canada

[3] CanmetENERGY, Nat Resources Canada, Devon, AB T9G 1A8, Canada

来源：

BIOMEDICAL OPTICS EXPRESS | 2012年 / 3卷 / 10期

基金：

加拿大创新基金会; 加拿大自然科学与工程研究理事会;

关键词：

SENTINEL LYMPH-NODES; OPTICAL-PROPERTIES; INDOCYANINE GREEN; GOLD; STABILITY; THERAPY; SILVER; SYSTEM; SHAPE; SIZE;

D O I：

10.1364/BOE.3.002500

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

In this study, we report for the first time the use of silica-coated superparamagnetic iron oxide nanoparticles (SPION) as contrast agents in biomedical photoacoustic imaging. Using frequency-domain photoacoustic correlation (the photoacoustic radar), we investigated the effects of nanoparticle size, concentration and biological media (e. g. serum, sheep blood) on the photoacoustic response in turbid media. Maximum detection depth and the minimum measurable SPION concentration were determined experimentally. The nanoparticle-induced optical contrast ex vivo in dense muscular tissues (avian pectus and murine quadricept) was evaluated and the strong potential of silica-coated SPION as a possible photoacoustic contrast agents was demonstrated. (C) 2012 Optical Society of America

引用

页码：2500 / 2509

页数：10

共 52 条

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