Increasing importance of Balamuthia mandrillaris

被引:104
作者
Matin, Abdul [1 ]
Siddiqui, Ruqaiyyah [1 ]
Jayasekera, Samantha [1 ]
Khan, Naveed Ahmed [1 ]
机构
[1] Univ London, Sch Biol & Chem Sci, London WC1E 7HX, England
关键词
D O I
10.1128/CMR.00056-07
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Balamuthia mandrillaris is an emerging protozoan parasite, an agent of granulomatous amoebic encephalitis involving the central nervous system, with a case fatality rate of >98% This review presents our current understanding of Balamuthia infections, their pathogenesis and pathophysiology, and molecular mechanisms associated with the disease, as well as virulence traits of Balamuthia that may be potential targets for therapeutic interventions and/or for the development of preventative measures. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
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收藏
页码:435 / 448
页数:14
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