Smoldering myeloma associated with zonisamide treatment

被引：4

作者：

Asai, S ^{[1
]}

Miyachi, H ^{[1
]}

Kobayashi, H ^{[1
]}

Hotta, T ^{[1
]}

Ando, Y ^{[1
]}

机构：

[1] Tokai Univ, Sch Med, Dept Lab Med, Isehara, Kanagawa 2591193, Japan

来源：

INTERNAL MEDICINE | 2002年 / 41卷 / 02期

关键词：

anticonvulsant; M-protein;

D O I：

10.2169/internalmedicine.41.138

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 39-year-old man was found to have hyperproteinemia after being treated with zonisamide for 10 years. Laboratory examination revealed a serum M-protein which consisted of IgG (lambda) and an increased number of plasma cells in the bone marrow, resulting in a diagnosis of smoldering myeloma. Considering his age, zonisamide was suspected to play an etiologic role in the occurrence of smoldering myeloma. Zonisamide was changed to sodium valproate. Subsequently the M-protein did not increase over 13 months. When zonisamide is used, the monitoring of serum levels of M-protein and patterns of gammaglobulin is warranted.

引用

页码：138 / 141

页数：4

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