Molecular, structural, and cellular biology of follitropin and follitropin receptor

被引：113

作者：

Dias, JA ^{[1
]}

Cohen, BD ^{[1
]}

Lindau-Shepard, B ^{[1
]}

Nechamen, CA ^{[1
]}

Peterson, AJ ^{[1
]}

Schmidt, A ^{[1
]}

机构：

[1] New York State Dept Hlth, Wadsworth Ctr, David Axelrod Inst Publ Hlth, Albany, NY 12208 USA

来源：

VITAMINS AND HORMONES - ADVANCES IN RESEARCH AND APPLICATIONS, VOL 64 | 2002年 / 64卷

关键词：

D O I：

10.1016/S0083-6729(02)64008-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Follitropin and the follitropin receptor are essential for normal gamete development in males and females. This review discusses the molecular genetics and structural and cellular biology of the follitropin/follitropin receptor system. Emphasis is placed on the human molecules when possible. The structure and regulation of the genes for the follitropin β subunit and the follitropin receptor is discussed. Control of systemic and cellular protein levels is explained. The structural biology of each protein is described, including protein structure, motifs, and activity relationships. Finally, the follitropin/follitropin receptor signal transduction system is discussed. © 2002.

引用

页码：249 / 322

页数：74

共 321 条

[1] Disulfide bond structure of human epidermal growth factor receptor [J].

Abe, Y ;

Odaka, M ;

Inagaki, F ;

Lax, I ;

Schlessinger, J ;

Kohda, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (18) :11150-11157

[2] The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction [J].

Abel, MH ;

Wootton, AN ;

Wilkins, V ;

Huhtaniemi, I ;

Knight, PG ;

Charlton, HM .

ENDOCRINOLOGY, 2000, 141 (05) :1795-1803

[3] SOMATOMEDIN-C AS AN AMPLIFIER OF FOLLICLE-STIMULATING-HORMONE ACTION - ENHANCED ACCUMULATION OF ADENOSINE-3',5'-MONOPHOSPHATE [J].

ADASHI, EY ;

RESNICK, CE ;

SVOBODA, ME ;

VANWYK, JJ .

ENDOCRINOLOGY, 1986, 118 (01) :149-155

[4] A KINASE-MEDIATED REGULATION OF GRANULOSA CELL-DERIVED INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEINS (IGFBPS) - DISPARATE RESPONSE SENSITIVITIES OF DISTINCT IGFBP SPECIES [J].

ADASHI, EY ;

RESNICK, CE ;

TEDESCHI, C ;

ROSENFELD, RG .

ENDOCRINOLOGY, 1993, 132 (04) :1463-1468

[5] Leptin antagonizes the insulin-like growth factor-I augmentation of steroidogenesis in granulosa and theca cells of the human ovary [J].

Agarwal, SK ;

Vogel, K ;

Weitsman, SR ;

Magoffin, DA .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (03) :1072-1076

[6] Clinical features of primary ovarian failure caused by a point mutation in the follicle-stimulating hormone receptor gene [J].

Aittomaki, K ;

Herva, R ;

Stenman, UH ;

Juntunen, K ;

Ylostalo, P ;

Hovatta, O ;

delaChapelle, A .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (10) :3722-3726

[7] MUTATION IN THE FOLLICLE-STIMULATING-HORMONE RECEPTOR GENE CAUSES HEREDITARY HYPERGONADOTROPIC OVARIAN FAILURE [J].

AITTOMAKI, K ;

LUCENA, JLD ;

PAKARINEN, P ;

SISTONEN, P ;

TAPANAINEN, J ;

GROMOLL, J ;

KASKIKARI, R ;

SANKILA, EM ;

LEHVASLAIHO, H ;

ENGEL, AR ;

NIESCHLAG, E ;

HUHTANIEMI, I ;

DELACHAPELLE, A .

CELL, 1995, 82 (06) :959-968

[8] Highly heterologous region in the N-terminal extracellular domain of reptilian follitropin receptors [J].

Akazome, Y ;

Ogasawara, O ;

Park, MK ;

Mori, T .

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1996, 104 (03) :374-381

[9] DEVELOPMENT OF A BIOASSAY FOR FSH USING A RECOMBINANT HUMAN FSH RECEPTOR AND A CAMP-RESPONSIVE LUCIFERASE REPORTER GENE [J].

ALBANESE, C ;

CHRISTINMAITRE, S ;

SLUSS, PM ;

CROWLEY, WF ;

JAMESON, JL .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1994, 101 (1-2) :211-219

[10] Detection of β2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET) [J].

Angers, S ;

Salahpour, A ;

Joly, E ;

Hilairet, S ;

Chelsky, D ;

Dennis, M ;

Bouvier, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) :3684-3689

← 1 2 3 4 5 6 7 8 9 10 →