mPer1 and mPer2 mutant mice show regular spatial and contextual learning in standardized tests for hippocampus-dependent learning

被引:28
作者
Zueger, M
Urani, A
Chourbaji, S
Zacher, C
Lipp, HP
Albrecht, U
Spanagel, R
Wolfer, DP
Gass, P
机构
[1] Heidelberg Univ, Cent Inst Mental Hlth, ZI, D-68159 Mannheim, Germany
[2] Univ Zurich, Inst Anat, CH-8006 Zurich, Switzerland
[3] Univ Fribourg, Div Biochem, Dept Med, CH-1700 Fribourg, Switzerland
关键词
clock genes; hippocampus; learning; knockout mice;
D O I
10.1007/s00702-005-0322-4
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Learning and memory, like most physiological processes, seem to be under the control of circadian rhythm. The recently cloned mPer1 and mPer2 genes play an important role in the regulation of the circadian rhythm. In this study, we tested mPer1 and mPer2 mutant mice in two different learning and memory paradigms, a water-maze place navigation task and contextual fear conditioning. In both learning tests, the hippocampus is critically involved. None of these learning types were affected by the mutations, suggesting that mPer1 and mPer2 do not play a major role in the regulation of hippocampus-dependent learning and memory.
引用
收藏
页码:347 / 356
页数:10
相关论文
共 56 条
[1]   Cocaine sensitization and reward are under the influence of circadian genes and rhythm [J].
Abarca, C ;
Albrecht, U ;
Spanagel, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (13) :9026-9030
[2]   A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light [J].
Albrecht, U ;
Sun, ZS ;
Eichele, G ;
Lee, CC .
CELL, 1997, 91 (07) :1055-1064
[3]  
Anagnostaras SG, 2001, HIPPOCAMPUS, V11, P8
[4]   Behavioral and neurochemical investigation of circadian time-place learning in the rat [J].
Aragona, BJ ;
Curtis, JT ;
Davidson, AJ ;
Wang, ZX ;
Stephan, FK .
JOURNAL OF BIOLOGICAL RHYTHMS, 2002, 17 (04) :330-344
[5]   Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock [J].
Bae, K ;
Jin, XW ;
Maywood, ES ;
Hastings, MH ;
Reppert, SM ;
Weaver, DR .
NEURON, 2001, 30 (02) :525-536
[6]  
Balschun D, 2003, J NEUROSCI, V23, P6304
[7]   RESTORATION OF CIRCADIAN BEHAVIORAL RHYTHMS BY GENE-TRANSFER IN DROSOPHILA [J].
BARGIELLO, TA ;
JACKSON, FR ;
YOUNG, MW .
NATURE, 1984, 312 (5996) :752-754
[8]  
BELING INGEBORG, 1929, ZEITSCHR VERGLEICH PHYSIOL, V9, P259, DOI 10.1007/BF00340159
[9]   DEFICITS IN CONDITIONED AVOIDANCE RESPONDING FOLLOWING ADRENALECTOMY AND CENTRAL NOREPINEPHRINE DEPLETION ARE DEPENDENT ON POSTSURGICAL RECOVERY PERIOD AND PHASE OF THE DIURNAL CYCLE [J].
BIALIK, RJ ;
PAPPAS, BA ;
ROBERTS, DCS .
BEHAVIORAL NEUROSCIENCE, 1984, 98 (05) :847-857
[10]   THE EFFECT OF CONSTANT LIGHT AND PHASE-SHIFTS ON A LEARNED TIME PLACE ASSOCIATION IN GARDEN WARBLERS (SYLVIA-BORIN) - HOURGLASS OR CIRCADIAN CLOCK [J].
BIEBACH, H ;
FALK, H ;
KREBS, JR .
JOURNAL OF BIOLOGICAL RHYTHMS, 1991, 6 (04) :353-365