Sustained drug release and antibacterial activity of ampicillin incorporated poly(methyl methacrylate)-nylon6 core/shell nanofibers

被引：77

作者：

Sohrabi, A. ^{[1
]}

Shaibani, P. M. ^{[1
]}

Etayash, H. ^{[2
]}

Kaur, K. ^{[2
]}

Thundat, T. ^{[1
]}

机构：

[1] Univ Alberta, Dept Chem & Mat Engn, Edmonton, AB T6G 2V4, Canada

[2] Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2E1, Canada

来源：

POLYMER | 2013年 / 54卷 / 11期

关键词：

Core/shell nanofibers; Sustained drug release; Release kinetics; POLY(LACTIC ACID); DELIVERY SYSTEMS; FIBERS; HYDROCHLORIDE; MATRIX;

D O I：

10.1016/j.polymer.2013.03.046

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理];

摘要：

In vitro drug release mechanism of core/shell nanofibers of poly(methyl methacrylate)(PMMA)-nylon6 fabricated through coaxial electrospinning containing different concentrations of ampicillin was investigated. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), Korsmeyer-Peppas equation and Fickian diffusion model were utilized to characterize the system. Antibacterial activity of the designed drug delivery system was investigated against Gram-positive Listeria innocua through optical density (OD) measurement. The system showed sustained drug release through three stages; although the release in stage I followed non-Fickian diffusion, Fickian diffusion was proven to be the release mechanism of stages II and III. A significant decrease in the diffusion coefficient from stage II to stage III was observed, which is believed to be the consequence of crystallization of fibers as a result of long-term incubation in an aqueous solution. Finally, the antibacterial activity of the system was verified by means of optical density (OD) measurements against Gram-positive L innocua. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：2699 / 2705

页数：7

共 25 条

[1]

Biodegradable amphiphilic multiblock copolymers and their implications for biomedical applications [J].