Toxicity of Doxorubicin (Dox) to different experimental organ systems

被引：437

作者：

Arivalagan Pugazhendhi ^{[1
]}

Edison, Thomas Nesakumar Jebakumar Immanuel ^{[2
]}

Velmurugan, Bharath Kumar ^{[3
]}

Jacob, Joe Antony ^{[4
]}

Karuppusamy, Indira ^{[5
]}

机构：

[1] Ton Duc Thang Univ, Fac Environm & Labour Safety, Innovat Green Prod Synth & Renewable Environm Dev, Ho Chi Minh City, Vietnam

[2] Yeungnam Univ, Sch Chem Engn, Gyongsan 38541, Gyeongbuk, South Korea

[3] China Med Univ Hosp, Environm Omics Dis Res Ctr, Taichung, Taiwan

[4] Southeast Univ, Sch Med, Zhongda Hosp, Dept Hematol & Oncol, Nanjing, Jiangsu, Peoples R China

[5] Indira Gandhi Ctr Atom Res, Corros Sci & Technol Div, Kalpakkam 603102, Tamil Nadu, India

来源：

LIFE SCIENCES | 2018年 / 200卷

关键词：

Doxorubicin; Mechanism; Toxicity; Multi-organ; Oxidative stress; PEGYLATED LIPOSOMAL DOXORUBICIN; INDUCED CARDIOTOXICITY; OXIDATIVE STRESS; MEDIATED APOPTOSIS; RADIATION RECALL; OVARIAN-CANCER; IN-VITRO; RATS; NANOPARTICLES; CELLS;

D O I：

10.1016/j.lfs.2018.03.023

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Doxorubicin (Dox) is a valuable anticancer drug for hematologic and solid tumors. Yet, it can cause multi-organ toxicities in various patients. Since toxicity evaluation is a major criterion to discuss for every experiment, the current mini-review focuses on the toxicity of Dox to multiple organs and suggests the most probable mechanism. Though several mechanisms have been suggested, the role of oxidative stress remains elusive among other mechanisms and remains the most probable mechanism for cardiotoxic effect of Dox.

引用

页码：26 / 30

页数：5

共 49 条

[1]

Testosterone Antagonizes Doxorubicin-Induced Senescence of Cardiomyocytes [J].