Application of Pharmacophore Models for the Design and Synthesis of New Anticonvulsant Drugs

被引:33
作者
Malawska, Barbara [1 ]
机构
[1] Jagiellonian Univ, Med Coll, Dept Pharmaceut Chem, PL-30688 Krakow, Poland
关键词
Pharmacophore models; anticonvulsants; Na-channel blockers; 4-aminobenzamide; N-phenylphthalimide; semicarbazones; GABA uptake inhibitors;
D O I
10.2174/1389557033488088
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The chemical diversity and various mechanisms of action of anticonvulsants make it difficult to identify a common pharmacophore. The present review outlines different pharmacophore models for anticonvulsant activity with emphasis on the development of new drugs. Some of them represent models for structurally different classes of compounds with similar mechanisms of action. Others represent pharmacophore models for similar chemical classes of compounds for which the mechanism of anticonvulsant action is not clear. A pharmacophore model for sodium channel blocking compounds, anticonvulsants with the phthalimide pharmacophore, a model for anticonvulsant semicarbazones, and a model for GABA uptake inhibitors are presented.
引用
收藏
页码:341 / 348
页数:8
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