The genetics of systemic lupus erythematosus

被引:13
作者
Alarcón-Riquelme, ME [1 ]
机构
[1] Uppsala Univ, Dept Genet & Pathol, S-75185 Uppsala, Sweden
关键词
genome scan; systemic lupus erythematosus; single nucleotide polymorphisms; microsatellites; association;
D O I
10.1016/j.jaut.2005.09.012
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 [免疫学];
摘要
For years the identification of candidate genes has been approached in various ways. The latest technology allows for whole genome SNP analysis in genetic association studies. These studies pose new challenges but also new possibilities. I hereby review what is known to date on lupus genetics and what challenges we are to overcome with the new available methods. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:46 / 48
页数:3
相关论文
共 27 条
[1]
Systemic lupus erythematosus in three ethnic groups.: XIX.: Natural history of the accrual of the American College of Rheumatology criteria prior to the occurrence of Criteria diagnosis [J].
Alarcón, GS ;
McGwin, G ;
Roseman, JM ;
Uribe, A ;
Fessler, BJ ;
Bastian, HM ;
Friedman, AW ;
Baethge, B ;
Vilá, LM ;
Reveille, JD .
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH, 2004, 51 (04) :609-615
[2]
Shared autoimmunity: the time has come. [J].
Alarcón-Segovia D. .
Current Rheumatology Reports, 2004, 6 (3) :171-174
[3]
ALARCONSEGOVIA D, 2003, SYSTEMIC LUPUS ERYTH
[4]
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis [J].
Begovich, AB ;
Carlton, VEH ;
Honigberg, LA ;
Schrodi, SJ ;
Chokkalingam, AP ;
Alexander, HC ;
Ardlie, KG ;
Huang, QQ ;
Smith, AM ;
Spoerke, JM ;
Conn, MT ;
Chang, M ;
Chang, SYP ;
Saiki, RK ;
Catanese, JJ ;
Leong, DU ;
Garcia, VE ;
McAllister, LB ;
Jeffery, DA ;
Lee, AT ;
Batliwalla, F ;
Remmers, E ;
Criswell, LA ;
Seldin, MF ;
Kastner, DL ;
Amos, CI ;
Sninsky, JJ ;
Gregersen, PK .
AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 75 (02) :330-337
[5]
Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein [J].
Boackle, SA ;
Holers, VM ;
Chen, XJ ;
Szakonyi, G ;
Karp, DR ;
Wakeland, EK ;
Morel, L .
IMMUNITY, 2001, 15 (05) :775-785
[6]
Drug-induced rheumatic syndromes [J].
Brogan, BL ;
Olsen, NJ .
CURRENT OPINION IN RHEUMATOLOGY, 2003, 15 (01) :76-80
[7]
Population stratification and spurious allelic association [J].
Cardon, LR ;
Palmer, LJ .
LANCET, 2003, 361 (9357) :598-604
[8]
Association study designs for complex diseases [J].
Cardon, LR ;
Bell, JI .
NATURE REVIEWS GENETICS, 2001, 2 (02) :91-99
[9]
GENETIC-ANALYSIS OF THE NZB CONTRIBUTION TO LUPUS-LIKE AUTOIMMUNE-DISEASE IN (NZB X NZW)F-1 MICE [J].
DRAKE, CG ;
BABCOCK, SK ;
PALMER, E ;
KOTZIN, BL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) :4062-4066
[10]
A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families [J].
Gaffney, PM ;
Kearns, GM ;
Shark, KB ;
Ortmann, WA ;
Selby, SA ;
Malmgren, ML ;
Rohlf, KE ;
Ockenden, TC ;
Messner, RP ;
King, RA ;
Rich, SS ;
Behrens, TW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :14875-14879