共 67 条
Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local β-structure
被引:444
作者:

von Bergen, M
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机构:
Max Planck Unit Struct Mol Biol, D-22607 Hamburg, Germany Max Planck Unit Struct Mol Biol, D-22607 Hamburg, Germany

Barghorn, S
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h-index: 0
机构:
Max Planck Unit Struct Mol Biol, D-22607 Hamburg, Germany Max Planck Unit Struct Mol Biol, D-22607 Hamburg, Germany

Li, L
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机构:
Max Planck Unit Struct Mol Biol, D-22607 Hamburg, Germany Max Planck Unit Struct Mol Biol, D-22607 Hamburg, Germany

Marx, A
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机构:
Max Planck Unit Struct Mol Biol, D-22607 Hamburg, Germany Max Planck Unit Struct Mol Biol, D-22607 Hamburg, Germany

Biernat, J
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机构:
Max Planck Unit Struct Mol Biol, D-22607 Hamburg, Germany Max Planck Unit Struct Mol Biol, D-22607 Hamburg, Germany

Mandelkow, EM
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Max Planck Unit Struct Mol Biol, D-22607 Hamburg, Germany Max Planck Unit Struct Mol Biol, D-22607 Hamburg, Germany

Mandelkow, E
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机构:
Max Planck Unit Struct Mol Biol, D-22607 Hamburg, Germany Max Planck Unit Struct Mol Biol, D-22607 Hamburg, Germany
机构:
[1] Max Planck Unit Struct Mol Biol, D-22607 Hamburg, Germany
关键词:
D O I:
10.1074/jbc.M105196200
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
The microtubule-associated protein tau is a natively unfolded protein in solution, yet it is able to polymerize into the ordered paired helical filaments (PHF) of Alzheimer's disease. In the splice isoforms lacking exon 10, this process is facilitated by the formation of P-structure around the hexapeptide motif PHF6 ((306)VQIVYK(311)) encoded by exon 11. We have investigated the structural requirements for PHF polymerization in the context of adult tau isoforms containing four repeats (including exon 10). In addition to the PHF6 motif there exists a related PHF6* Motif ((275)VQIINK(280)) in the repeat encoded by the alternatively spliced exon 10. We show that this PHF6* motif also promotes aggregation by the formation of P-structure and that there is a cross-talk between the two hexapeptide motifs during PHF aggregation. We also show that two of the tau mutations found in hereditary frontotemporal dementias, Delta K280 and P301L, have a much stronger tendency for PHF aggregation which correlates with their high propensity for beta -structure around the hexapeptide motifs.
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页码:48165 / 48174
页数:10
相关论文
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