Rapid selection of complement-inhibiting protein variants in group A Streptococcus epidemic waves

被引：72

作者：

Hoe, NP

Nakashima, K

Lukomski, S

Grigsby, D

Liu, MY

Kordari, P

Dou, SJ

Pan, X

Vuopio-Varkila, J

Salmelinna, S

McGeer, A

Low, DE

Schwartz, B

Schuchat, A

Naidich, S

De Lorenzo, D

Fu, YX

Musser, JM

机构：

[1] Natl Publ Hlth Inst, Dept Bacteriol, FIN-00300 Helsinki, Finland

[2] Mt Sinai Hosp, Dept Microbiol, Toronto, ON M5G 1X5, Canada

[3] Univ Toronto, Toronto, ON M5G 1X5, Canada

[4] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA

[5] Genomics, New York, NY 10013 USA

[6] Univ Texas, Hlth Sci Ctr, Ctr Human Genet, Houston, TX 77030 USA

来源：

NATURE MEDICINE | 1999年 / 5卷 / 08期

关键词：

D O I：

10.1038/11369

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Serotype M1 group A Streptococcus strains cause epidemic waves of human infections long thought to be mono- or pauciclonal. The gene encoding an extracellular group A Streptococcus protein (streptococcal inhibitor of complement) that inhibits human complement was sequenced in 1,132 M1 strains recovered from population-based surveillance of infections in Canada, Finland and the United States. Epidemic waves are composed of strains expressing a remarkably heterogeneous array of variants of streptococcal inhibitor of complement that arise very rapidly by natural selection on mucosal surfaces. Thus, our results enhance the understanding of pathogen population dynamics in epidemic waves and infectious disease reemergence.

引用

页码：924 / 929

页数：6

共 34 条

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