Exosomal tumor-suppressive microRNAs as novel cancer therapy "Exocure" is another choice for cancer treatment

被引：63

作者：

Kosaka, Nobuyoshi ^{[1
]}

Takeshita, Fumitaka ^{[1
]}

Yoshioka, Yusuke ^{[1
,2
,4
]}

Hagiwara, Keitaro ^{[1
,3
]}

Katsuda, Takeshi ^{[1
]}

Ono, Makiko ^{[1
]}

Ochiya, Takahiro ^{[1
]}

机构：

[1] Natl Canc Ctr, Res Inst, Div Mol & Cellular Med, Chuo Ku, Tokyo 1040045, Japan

[2] Waseda Univ, Grad Sch Sci & Engn, Integrat Biosci & Biomed Engn, Tokyo 1628480, Japan

[3] Tokyo Inst Technol, Grad Sch Biosci & Biotechnol, Dept Biol Informat, Yokohama, Kanagawa 2268501, Japan

[4] Japan Soc Promot Sci, Tokyo, Japan

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2013年 / 65卷 / 03期

基金：

日本学术振兴会;

关键词：

Tumor-suppressive microRNA; Secretory microRNAs; Cell-cell communication; Tumor initiation; Exosomes; Small RNA therapy; Drug delivery system; Exosome; Microvesicle; PROSTATE-CANCER; CERVICAL-CANCER; SMALL RNAS; LET-7; EXPRESSION; SECRETION; MECHANISM; CELLS; PROGRESSION; MIR-143;

D O I：

10.1016/j.addr.2012.07.011

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

MicroRNAs (miRNAs) act to fine-tune cellular responses in a variety of biological circumstances such as development, organogenesis, and homeostasis. The dysregulation of miRNA expression accelerates disease progression, including metabolic disease, immunological diease and cancer, through the gene network disorder. Therefore, understanding the miRNA maturation process may unravel the mechanisms of cancer malignancy; however, the life of miRNA has not been clarified. In this article, we summarize the recent findings regarding the novel forms of miRNA, especially secretory miRNAs, focusing on exosomal miRNAs. Recent research has revealed that exosomal miRNAs affect many aspects of physiological and pathological conditions, and may be useful as novel therapy. Here, we propose a method for the delivery of tumor-suppressive miRNAs to desired sites using exosomes, and we named this method "exocure". (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：376 / 382

页数：7

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