Binding, Internalization, and Antigen Presentation of Vaccine-Loaded Nanoengineered Capsules in Blood

被引：116

作者：

De Rose, Robert ^{[2
]}

Zelikin, Alexander N. ^{[1
]}

Johnston, Angus P. R. ^{[1
]}

Sexton, Amy ^{[2
]}

Chong, Siow-Feng ^{[1
]}

Cortez, Christina ^{[1
]}

Mulholland, William ^{[1
]}

Caruso, Frank ^{[1
]}

Kent, Stephen J. ^{[2
]}

机构：

[1] Univ Melbourne, Dept Chem & Biomol Engn, Ctr Nanosci & Nanotechnol, Melbourne, Vic 3010, Australia

[2] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia

来源：

ADVANCED MATERIALS | 2008年 / 20卷 / 24期

关键词：

D O I：

10.1002/adma.200801826

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanoengineered microcapsules (shown in green) can be used to encapsulate vaccine antigens conferring protection of the cargo until the capsules are taken up by specialized antigen presenting cells in human blood such as dendritic cells (cell membrane in red, nucleus in blue). This technique offers potential applications for in vivo vaccine delivery.

引用

页码：4698 / +

页数：7

共 33 条

[1] Nanoengineering of inorganic and hybrid hollow spheres by colloidal templating [J].

Caruso, F ;

Caruso, RA ;

Möhwald, H .

SCIENCE, 1998, 282 (5391) :1111-1114

[2] Enhanced cellular immunity in macaques following a novel peptide immunotherapy [J].

Chea, S ;

Dale, CJ ;

De Rose, R ;

Rantshaw, IA ;

Kent, SJ .

JOURNAL OF VIROLOGY, 2005, 79 (06) :3748-3757

[3] AIDS research - Did Merck's failed HIV vaccine cause harm [J].

Cohen, Jon .

SCIENCE, 2007, 318 (5853) :1048-1049

[4] Therapeutic immunization with human immunodeficiency virus type 1 (HIV-1) peptide-loaded dendritic cells is safe and induces immunogenicity in HIV-1-Infected individuals [J].

Connolly, Nancy C. ;

Whiteside, Theresa L. ;

Wilson, Cara ;

Kondragunta, Venkatswarlu ;

Rinaldo, Charles R. ;

Riddler, Sharon A. .

CLINICAL AND VACCINE IMMUNOLOGY, 2008, 15 (02) :284-292

[5]

De Geest BG, 2007, CHEM SOC REV, V36, P636, DOI 10.1039/b600460c

[6] Control of viremia and prevention of AIDS following immunotherapy of SIV-infected macaques with peptide-pulsed blood [J].

De Rose, Robert ;

Fernandez, Caroline S. ;

Smith, Miranda Z. ;

Batten, C. Jane ;

Alcantara, Sheilajen ;

Peut, Vivienne ;

Rollman, Erik ;

Loh, Liyen ;

Mason, Rosemarie D. ;

Wilson, Kim ;

Law, Matthew G. ;

Handley, Amanda J. ;

Kent, Stephen J. .

PLOS PATHOGENS, 2008, 4 (05)

[7]

Donath E, 1998, ANGEW CHEM INT EDIT, V37, P2202, DOI 10.1002/(SICI)1521-3773(19980904)37:16<2201::AID-ANIE2201>3.0.CO

[8]

2-E

[9] Vaccine-induced T cells control reversion of AIDS virus immune escape mutants [J].

Fernandez, Caroline S. ;

Smith, Miranda Z. ;

Batten, C. Jane ;

De Rose, Robert ;

Reece, Jeanette C. ;

Rollman, Erik ;

Venturi, Vanessa ;

Davenport, Miles P. ;

Kent, Stephen J. .

JOURNAL OF VIROLOGY, 2007, 81 (08) :4137-4144

[10] Stabilization of DNA multilayer films through oligonucleotide crosslinking [J].

Johnston, Angus P. R. ;

Caruso, Frank .

SMALL, 2008, 4 (05) :612-618

← 1 2 3 4 →