Novel antifungal drugs

被引：64

作者：

DiDomenico, B ^{[1
]}

机构：

[1] Schering Plough Res Inst, Kenilworth, NJ 07033 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 1999年 / 2卷 / 05期

关键词：

D O I：

10.1016/S1369-5274(99)00009-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

There have been many new developments in antifungal therapy in the past few years. Some antifungal drugs have been reformulated to reduce toxicity (e.g, new lipid formulations of polyenes), and new derivatives of drugs have been developed to enhance potencies. The search for unique drug targets will be enhanced by the availability of sequencing data from whole genome sequencing projects.

引用

收藏

页码：509 / 515

页数：7

相关论文

共 85 条

[1] Evaluation of the echinocandin antifungal MK-0991 (L-743,872): Efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis [J].

Abruzzo, GK ;

Flattery, AM ;

Gill, CJ ;

Kong, L ;

Smith, JG ;

Pikounis, VB ;

Balkovec, JM ;

Bouffard, AF ;

Dropinski, JF ;

Rosen, H ;

Kropp, H ;

Bartizal, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (11) :2333-2338

[2]

AVILES P, 1998, 38 ANN INT C ANT AG, pJ56

[3] In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872) [J].

Bartizal, K ;

Gill, CJ ;

Abruzzo, GK ;

Flattery, AM ;

Kong, L ;

Scott, PM ;

Smith, JG ;

Leighton, CE ;

Bouffard, A ;

Dropinski, JF ;

Balkovec, J .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (11) :2326-2332

[4] AmBisome (Liposomal amphotericin B): A comparative review [J].

Boswell, GW ;

Buell, D ;

Bekersky, I .

JOURNAL OF CLINICAL PHARMACOLOGY, 1998, 38 (07) :583-592

[5] Translation elongation factor 2 is part of the target for a new family of antifungals [J].

Capa, L ;

Mendoza, A ;

Lavandera, JL ;

de las Heras, FG ;

García-Bustos, JF .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (10) :2694-2699

[6]

CHAVEZ M, 1998, 38 ANN INT C AG CHEM, P452

[7] Efficacy of nikkomycin Z against experimental pulmonary blastomycosis [J].

Clemons, KV ;

Stevens, DA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (09) :2026-2028

[8] Comparison of the in-vitro activity of voriconazole (UK-109,496), itraconazole and amphotericin B against clinical isolates of Aspergillus fumigatus [J].

Cuenca-Estrella, M ;

Rodríguez-Tudela, JL ;

Mellado, E ;

Martínez-Suárez, JV ;

Monzón, A .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1998, 42 (04) :531-533

[9] Echinocandins and pneumocandins - a new antifungal class with a novel mode of action [J].

Denning, DW .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1997, 40 (05) :611-614

[10] Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity [J].

Devadas, B ;

Freeman, SK ;

Zupec, ME ;

Lu, HF ;

Nagarajan, SR ;

Kishore, NS ;

Lodge, JK ;

Kuneman, DW ;

McWherter, CA ;

Vinjamoori, DV ;

Getman, DP ;

Gordon, JI ;

Sikorski, JA .

JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (16) :2609-2625

← 1 2 3 4 5 6 7 8 9 →