Impact of Multi-Walled Carbon Nanotubes on Aquatic Species

被引：44

作者：

Asharani, P. V. ^{[1
]}

Serina, N. G. B. ^{[1
]}

Nurmawati, M. H. ^{[1
]}

Wu, Y. L. ^{[2
]}

Gong, Z. ^{[2
]}

Valiyaveettil, S. ^{[1
]}

机构：

[1] Natl Univ Singapore, Fac Sci, Dept Chem, Singapore 117543, Singapore

[2] Natl Univ Singapore, Dept Biol Sci, Singapore 117543, Singapore

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2008年 / 8卷 / 07期

关键词：

MWCNT; Capping Agent; Zebrafish; Toxicity; Hours Post Fertilization (hpf); Apoptosis;

D O I：

10.1166/jnn.2008.432

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

To understand the environmental impacts of carbon nanotubes (CNTs), the toxicity study was carried out with water-soluble multi-walled carbon nanotubes (MWCNTs) using zebrafish (Danio rerio) as a model system. Zebrafish embryos were treated with different concentrations of MWCNTs. Teratogenic effects were evaluated through changes in embryonic development after 24 hours post-fertilization (hpf), 48 hpf and 72 hpf. No observable effect concentration (NOEC) was at 40 mu g/mL. Lowest effect concentration (LOEC) of MWCNTs which caused significant phenotypic defects in zebrafish embryo was 60 mu g/mL. At concentration above 60 mu g/mL, slimy mucus like coating was observed around the embryo. At high concentrations, MWCNTs was found to be involved in the apoptosis, delayed hatching and formation of abnormal spinal chords. Thus, the toxicity of multi-walled carbon nanotubes is concentration dependent.

引用

页码：3603 / 3609

页数：7

共 33 条

[1] Biosensors based on carbon nanotubes [J].

Balasubramanian, Kannan ;

Burghard, Marko .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2006, 385 (03) :452-468

[2] Multi-walled carbon nanotubes induce T lymphocyte apoptosis [J].

Bottini, M ;

Bruckner, S ;

Nika, K ;

Bottini, N ;

Bellucci, S ;

Magrini, A ;

Bergamaschi, A ;

Mustelin, T .

TOXICOLOGY LETTERS, 2006, 160 (02) :121-126

[3]

Brand M, 1996, DEVELOPMENT, V123, P179

[4]

CHARLES RM, 2003, DRUG DISCOV, V2, P29

[5] Effect of carbon nanotubes on developing zebrafish (Danio rerio) embryos [J].

Cheng, Jinping ;

Flahaut, Emmanuel ;

Cheng, Shuk Han .

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2007, 26 (04) :708-716

[6]

DETRICH HW, 2004, METHODS CELL BIOL ZE, V76

[7] Molecular characterization of the cytotoxic mechanism of multiwall carbon nanotubes and nano-onions on human skin fibroblast [J].

Ding, LH ;

Stilwell, J ;

Zhang, TT ;

Elboudwarej, O ;

Jiang, HJ ;

Selegue, JP ;

Cooke, PA ;

Gray, JW ;

Chen, FQF .

NANO LETTERS, 2005, 5 (12) :2448-2464

[8] Ultrafast absorptive and refractive nonlinearities in multiwalled carbon nanotube films [J].

Elim, HI ;

Ji, W ;

Ma, GH ;

Lim, KY ;

Sow, CH ;

Huan, CHA .

APPLIED PHYSICS LETTERS, 2004, 85 (10) :1799-1801

[9] Preliminary results on the pathogenic effects of intratracheal exposure to one-dimensional nanocarbons [J].

Grubek-Jaworska, H ;

Nejman, P ;

Czuminska, K ;

Przybylowski, T ;

Huczko, A ;

Lange, H ;

Bystrzejewski, M ;

Baranowski, P ;

Chazan, R .

CARBON, 2006, 44 (06) :1057-1063

[10] Nitric acid purification of single-walled carbon nanotubes [J].

Hu, H ;

Zhao, B ;

Itkis, ME ;

Haddon, RC .

JOURNAL OF PHYSICAL CHEMISTRY B, 2003, 107 (50) :13838-13842

← 1 2 3 4 →