Aggrecanase and Aggrecan Degradation in Osteoarthritis: a Review

被引：179

作者：

Huang, K. ^{[1
]}

Wu, L. D. ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Med, Hosp 2, Dept Orthopaed, Hangzhou 310009, Zhejiang, Peoples R China

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2008年 / 36卷 / 06期

关键词：

AGGRECANASE INHIBITORS; AGGRECANASE; AGGRECAN; ADAMTS; OSTEOARTHRITIS;

D O I：

10.1177/147323000803600601

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

Aggrecanase-mediated aggrecan degradation is a significant event in early-stage osteoarthritis (OA). Aggrecanases belonging to the 'A Disintegrin And Metalloproteinase with ThromboSpondin motifs' (ADAMTS) family of proteinases play a significant role in aggrecan depletion in osteoarthritic cartilage. There has been considerable interest in the possible role of these aggrecanases, especially ADAMTS-4 and ADAMTS-5, as therapeutic targets in OA. This article discusses recent data regarding ADAMTS-4 and ADAMTS-5 in OA, with emphasis on the relationship between aggrecanase and aggrecan degradation as well as the role of aggrecanase in OA.

引用

页码：1149 / 1160

页数：12

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