BiP regulates autoimmune inflammation and tissue damage

被引：46

作者：

Panayi, GS ^{[1
]}

Corrigall, VM ^{[1
]}

机构：

[1] Kings Coll London, GKT Sch Med, Dept Acad Rheumatol, Guys Hosp, London SE1 9RT, England

来源：

AUTOIMMUNITY REVIEWS | 2006年 / 5卷 / 02期

关键词：

BiP; immunomodulation arthritis; anti-inflammatory; stress proteins; chaperones;

D O I：

10.1016/j.autrev.2005.08.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The endoplasmic reticulum chaperone BiP, in addition to its many important intracellular functions, has anti-inflammatory and immunomodulatory properties when present in the extracellular environment by the stimulation of an anti-inflammatory gene programme from human monocytes and by the development of T-cells that secrete regulatory cytokines such as interleukin-10 and interleukin-4. It can both prevent as well as treat ongoing collagen-induced arthritis. It is, therefore, a potential new biologic therapy for rheumatoid arthritis. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：140 / 142

页数：3

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