Synthesis and metalation of trifluoromethylpyrimidines. Metalation of diazines .16.

被引：25

作者：

Ple, N

Turck, A

Heynderickx, A

Queguiner, G

机构：

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1997年 / 34卷 / 02期

关键词：

D O I：

10.1002/jhet.5570340234

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new route to trifluoromethylpyrimidines is described. Lithiation of trifluoromethylpyrimidines was successfully achieved and was used to synthesize new pyrimidine derivatives. A new synthetic route to a biologically active molecule with antimycotic activities is reported.

引用

页码：551 / 556

页数：6

共 26 条

[1] METALATION OF 1,3-BIS(TRIFLUOROMETHYL)BENZENE BY N-BUTYLLITHIUM
AEBERLI, P
HOULIHAN, WJ
[J]. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1974, 67 (03) : 321 - 325
[2] NMR-STUDY OF SOME SUBSTITUTED 1,3- AND 1,4-BISTRIFLUOROMETHYLBENZENES
BARTLE, KD
HALLAS, G
HEPWORTH, JD
[J]. ORGANIC MAGNETIC RESONANCE, 1973, 5 (10): : 479 - 481
[3] A REMARKABLY SIMPLE PREPARATION OF (TRIFLUOROMETHYL)CADMIUM AND (TRIFLUOROMETHYL) ZINC REAGENTS DIRECTLY FROM DIFLUORODIHALOMETHANES
BURTON, DJ
WIEMERS, DM
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (17) : 5014 - 5015
[4] BURTON DJ, 1986, J AM CHEM SOC, V108, P832
[5] METHYL FLUOROSULFONYLDIFLUOROACETATE - A NEW TRIFLUOROMETHYLATING AGENT
CHEN, QY
WU, SW
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1989, (11) : 705 - 706
[6] STUDIES ON FLUOROALKYLATION AND FLUOROALKOXYLATION .33. DIRECT TRIFLUOROMETHYLATION OF ARYL HALIDES WITH FLUOROSULPHONYLDIFLUOROMETHYL IODIDE IN THE PRESENCE OF COPPER - AN ELECTRON-TRANSFER INDUCED PROCESS
CHEN, QY
WU, SW
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1989, (12): : 2385 - 2387
[7] CLARK HC, 1963, ADV FLUORINE CHEM, V3, P21
[8] METALLATION OF 1,3-BISTRIFLUOROMETHYLBENZENE AND NN-DIMETHYL-3,5-BIS-TRIFLUOROMETHYLANILINE
GROCOCK, DE
JONES, TK
HALLAS, G
HEPWORTH, JD
[J]. JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1971, (19): : 3305 - &
[9] KATSOULOS G, 1991, SYNLETT, P731
[10] KATSOULOS G, 1993, THESIS LAUSANNE

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