Venous thromboembolism prophylaxis in major orthopaedic surgery: A multicenter, prospective, observational study

被引：24

作者：

Altintas, Faik ^{[1
]}

Gurbuz, Hakan

Erdemli, Buelent ^{[2
]}

Atilla, Buelent ^{[3
]}

Ustaoglu, Recep Guer ^{[4
]}

Ozic, Ugur ^{[5
]}

Savk, Oener ^{[6
]}

Bayram, Hueseyin ^{[7
]}

Memik, Recep ^{[8
]}

Akgun, Isik ^{[9
]}

Gogus, Abdullah

Pestilci, Fatih ^{[10
]}

Konal, Adnan ^{[11
]}

Argun, Mahmut ^{[12
]}

Ozturk, Irfan ^{[13
]}

Dabak, Nevzat ^{[14
]}

Bilgen, Oemer Faruk ^{[15
]}

Serin, Erhan ^{[16
]}

Onder, Cetin ^{[17
]}

Simsek, Aykim ^{[18
]}

Tozun, Remzi ^{[19
]}

Kinik, Hakan ^{[2
]}

机构：

[1] Yeditepe Univ, Tip Fak, Ortopedi & Travmatol Anabilim Dali, TR-34752 Istanbul, Turkey

[2] Ankara Univ, Tip Fak, TR-06100 Ankara, Turkey

[3] Hacettepe Univ, Tip Fak, Ankara, Turkey

[4] Izmir Ataturk Egitim & Arastirma Hastanesi, Izmir, Turkey

[5] Celal Bayar Univ, Tip Fak, Manisa, Turkey

[6] Adnan Menderes Univ, Tip Fak, Aydin, Turkey

[7] Cukurova Univ, Tip Fak, Adana, Turkey

[8] Selcuk Univ, Tip Fak, Konya, Turkey

[9] Istanbul Univ, Cerrahpasa Tip Fak, Istanbul, Turkey

[10] Ankara Diskapi Yildirim Beyazit Egitim & Arastirm, Ankara, Turkey

[11] Istanbul Kartal Yavuz Selim Devlet Hastanesi, Istanbul, Turkey

[12] Erciyes Univ, Tip Fak, Kayseri, Turkey

[13] Istanbul Sisli Etfal Egitim & Arastirma Hastanesi, Istanbul, Turkey

[14] Ondokuz Mayis Univ, Tip Fak, TR-55139 Kurupelit, Turkey

[15] Uludag Univ, Tip Fak, Bursa, Turkey

[16] Firat Univ, Tip Fak, Elazig, Turkey

[17] Karadeniz Tech Univ, Tip Fak, Trabzon, Turkey

[18] Gazi Univ, Tip Fak, Ankara, Turkey

[19] Istanbul Univ, Istanbul Tip Fak, Istanbul, Turkey

来源：

ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA | 2008年 / 42卷 / 05期

关键词：

Anticoagulants/therapeutic use; arthroplasty; replacement; hip; knee; postoperative complications; risk factors; thromboembolism; venous thrombosis;

D O I：

10.3944/AOTT.2008.322

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Objectives: We investigated risk factors for venous thromboembolism (VTE), prophylaxis measures employed, and incidence of symptomatic deep venous thrombosis (DVT) and pulmonary embolism (PE) in patients undergoing major orthopaedic surgery (MOS). Methods: An open, multicenter, prospective, observational study was conducted in 21 medical centers, comprising 899 patients. Of these. 316 patients (35.2%) underwent total hip arthroplasty (THA), 328 patients (36.5%) underwent total knee arthroplasty (TKA), and 255 patients (28.4%) underwent surgery for hip fractures (HF). Pharmacologic prophylaxis was employed in all the patients. Results: Risk factors for VTE were seen in 73.2% of the patents. the most common being obesity (72%) and prolonged immobilization (36.3%). Low-molecular-weight heparin (91.1%) and fondaparinux (8.9%) were used for prophylaxis, which was short-term in 273 patients (30.4%) and long-term in 626 patients (69.6%). Mechanical prophylaxis was performed with compression stockings in 610 patients (67.9%) and by intermittent pneumatic compression in 67 patients (7.5%). During three-months of follow-up, symptomatic DVT and PE were seen in eight (0.9%) and four patients (0.4%), respectively. Mortality occurred in 10 patients (1.1%). Complications of major and minor bleeding were seen in eight (0.9%) and 40 (4.5%) patients, respectively. Conclusion: Effective VTE prophylaxis is associated with low risk of clinically apparent DVT and PE in MOS.

引用

页码：322 / 327

页数：6

共 23 条

[1]

ALTINTAS F, 2000, ACTA ORTHOP TRAUMATO, V34, P100

[2]

Altintas F., 1995, ACTA ORTHOP TRAUMATO, V29, P197

[3]

Risk factors for venous thromboembolism [J].