Infectious triggers for inflammatory neurological diseases

被引:16
作者
Wucherpfennig, KW [1 ]
机构
[1] Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA
关键词
D O I
10.1038/nm0502-455
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Do autoimmune diseases develop 'spontaneously' or are they induced by environmental triggers, such as infectious agents? This is a central- and challenging-question in the autoimmunity field. A new study in this issue provides strong evidence for a virus-induced autoimmune process in a human neurological disease.
引用
收藏
页码:455 / 457
页数:3
相关论文
共 12 条
[1]   AMINO-ACID HOMOLOGY BETWEEN THE ENCEPHALITOGENIC SITE OF MYELIN BASIC-PROTEIN AND VIRUS - MECHANISM FOR AUTOIMMUNITY [J].
FUJINAMI, RS ;
OLDSTONE, MBA .
SCIENCE, 1985, 230 (4729) :1043-1045
[2]  
Hausmann S, 1999, J IMMUNOL, V162, P5389
[3]   Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry [J].
Horwitz, MS ;
Bradley, LM ;
Harbertson, J ;
Krahl, T ;
Lee, J ;
Sarvetnick, N .
NATURE MEDICINE, 1998, 4 (07) :781-785
[4]   HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy [J].
Jeffery, KJM ;
Usuku, K ;
Hall, SE ;
Matsumoto, W ;
Taylor, GP ;
Procter, J ;
Bunce, M ;
Ogg, GS ;
Welsh, KI ;
Weber, JN ;
Lloyd, AL ;
Nowak, MA ;
Nagai, M ;
Kodama, D ;
Izumo, S ;
Osame, M ;
Bangham, CRM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (07) :3848-3853
[5]   Autoimmunity due to molecular mimicry as a cause of neurological disease [J].
Levin, MC ;
Lee, SM ;
Kalume, F ;
Morcos, Y ;
Dohan, FC ;
Hasty, KA ;
Callaway, JC ;
Zunt, J ;
Desiderio, DM ;
Stuart, JM .
NATURE MEDICINE, 2002, 8 (05) :509-513
[6]   Neuronal molecular mimicry in immune-mediated neurologic disease [J].
Levin, MC ;
Krichavsky, M ;
Berk, J ;
Foley, S ;
Rosenfeld, M ;
Dalmau, J ;
Chang, G ;
Posner, JB ;
Jacobson, S .
ANNALS OF NEUROLOGY, 1998, 44 (01) :87-98
[7]   Immunopathogenesis of human T cell lymphotropic virus type I-associated myelopathy [J].
Nagai, M ;
Jacobson, S .
CURRENT OPINION IN NEUROLOGY, 2001, 14 (03) :381-386
[8]  
Olsen JK, 2001, J CLIN INVEST, V108, P311
[9]   Analysis of the relationship between viral infection and autoimmune disease [J].
Panoutsakopoulou, V ;
Sanchirico, ME ;
Huster, KM ;
Jansson, M ;
Granucci, F ;
Shim, DJ ;
Wucherpfennig, KW ;
Cantor, H .
IMMUNITY, 2001, 15 (01) :137-147
[10]   CAMPYLOBACTER-JEJUNI INFECTION AND GUILLAIN-BARRE-SYNDROME [J].
REES, JH ;
SOUDAIN, SE ;
GREGSON, NA ;
HUGHES, RAC .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (21) :1374-1379