Protease M/neurosin mRNA is expressed in mature oligodendrocytes

被引：66

作者：

Yamanaka, H ^{[1
]}

He, XP ^{[1
]}

Matsumoto, K ^{[1
]}

Shiosaka, S ^{[1
]}

Yoshida, S ^{[1
]}

机构：

[1] Nara Inst Sci & Technol, Div Struct Cell Biol, Nara 6300101, Japan

来源：

MOLECULAR BRAIN RESEARCH | 1999年 / 71卷 / 02期

关键词：

serine protease; proteolipid protein; development;

D O I：

10.1016/S0169-328X(99)00187-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

No proteases have been identified to be oligodendrocyte-specific though there are phenomena in which proteases may be committed. We have cloned a cDNA for mouse homologue of protease M/neurosin, serine protease, and localized its mRNA in the mouse brain. The cDNA and the deduced amino acid sequences were 66% identical to those of human protease M/neurosin. In situ hybridization histochemistry revealed that the mRNA was localized in the mature oligodendrocytes which expressed proteolipid protein mRNA. Developmentally, protease M/neurosin mRNA was expressed by oligodendrocytes 2 to 7 days after the maturation. Thus, protease M/neurosin may be important to the processes occurring after the maturation of oligodendrocytes such as myelination or turnover of the proteins in the myelin. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：217 / 224

页数：8

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