Catalytic Enantioselective α-Arylation of Carbonyl Compounds

被引：72

作者：

Burtoloso, Antonio C. B. ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Paulo, Brazil

来源：

SYNLETT | 2009年 / 02期

关键词：

enolates; alpha-arylation; carbonyl compounds; palladium; nickel; quaternary benzylic centers; ASYMMETRIC ARYLATION; RATE ACCELERATION; CARBENE LIGANDS; PALLADIUM; CONSTRUCTION; COMPLEXES; KETONES;

D O I：

10.1055/s-0028-1087673

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective creation of benzylic quaternary centers still is a continuous challenge to many synthetic organic chemists. Among the existing methods for installation of this type of center, the direct asymmetric alpha-arylation of carbonyl compounds is very attractive due to the ready availability of the coupling substrates. Herein, we present some new tools to the catalytic asymmetric alpha-arylation of carbonyl compounds that overcame many of the drawbacks posted in previous methods for this type of reaction.

引用

页码：320 / 327

页数：8

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