Embryonic cerebellar granule cells are resistant to necrosis induced by homocysteine

被引：15

作者：

Foister, NSL ^{[1
]}

Oldreive, CE ^{[1
]}

Mackie, JB ^{[1
]}

Doherty, GH ^{[1
]}

机构：

[1] Univ St Andrews, Sch Biol, St Andrews KY16 9TS, Fife, Scotland

来源：

DEVELOPMENTAL BRAIN RESEARCH | 2005年 / 160卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

caspase; cerebellum; development; homocysteine; mouse; neurodegeneration;

D O I：

10.1016/j.devbrainres.2005.07.011

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hyperhomocysteinemia is a risk factor for a range of neurodegenerative conditions, yet its effects in the developing nervous system have been poorly elucidated. We studied the in vitro response of cerebellar granule neurons (CGCs) to homocysteine. We have shown that embryonic CGCs are resistant to homocysteine-induced neurotoxicity, whilst postnatal CGCs are not. This is the first demonstration of a neuronal population undergoing a developmental switch in their response to homocysteine. Greater understanding of this change may have important implications for both neurodegenerative conditions and neurodevelopmental disorders. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：85 / 89

页数：5

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