IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (H1N1) Virus

被引：139

作者：

Li, Chenggang ^{[1
]}

Yang, Penghui ^{[2
]}

Sun, Yang ^{[1
]}

Li, Taisheng ^{[3
,4
]}

Wang, Chen ^{[1
,5
]}

Wang, Zhong ^{[4
,6
]}

Zou, Zhen ^{[1
]}

Yan, Yiwu ^{[1
]}

Wang, Wei ^{[1
]}

Wang, Chen ^{[1
,5
]}

Chen, Zhongwei ^{[2
]}

Xing, Li ^{[2
]}

Tang, Chong ^{[2
]}

Ju, Xiangwu ^{[1
]}

Guo, Feng ^{[1
]}

Deng, Jiejie ^{[1
]}

Zhao, Yan ^{[1
]}

Yang, Peng ^{[1
]}

Tang, Jun ^{[1
]}

Wang, Huanling ^{[3
,4
]}

Zhao, Zhongpeng ^{[2
]}

Yin, Zhinan ^{[7
]}

Cao, Bin ^{[5
]}

Wang, Xiliang ^{[2
]}

Jiang, Chengyu ^{[1
]}

机构：

[1] Tsinghua Univ, Chinese Acad Med Sci, Peking Union Med Coll,Ctr Translational Med, State Key Lab Med Mol Biol,Inst Basic Med Sci, Beijing 100005, Peoples R China

[2] Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogens & Biosecur, Beijing 100071, Peoples R China

[3] Chinese Acad Med Sci, Dept Infect Dis, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China

[4] Peking Union Med Coll, Beijing 100730, Peoples R China

[5] Capital Med Univ, Beijing Chao Yang Hosp, Beijing Inst Resp Med, Beijing 100020, Peoples R China

[6] Chinese Acad Med Sci, Emergency Dept, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China

[7] Nankai Univ, Coll Life Sci, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China

来源：

CELL RESEARCH | 2012年 / 22卷 / 03期

基金：

中国国家自然科学基金;

关键词：

cytokine; acute lung injury; S-OIV H1N1; T-CELLS; AUTOIMMUNE INFLAMMATION; A(H1N1) INFECTION; INTERLEUKIN-17; PATHOGENESIS; OSELTAMIVIR; CYTOKINE; TRANSMISSION; FERRETS; ROLES;

D O I：

10.1038/cr.2011.165

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The 2009 flu pandemic involved the emergence of a new strain of a swine-origin H1N1 influenza virus (S-OIV H1N1) that infected almost every country in the world. Most infections resulted in respiratory illness and some severe cases resulted in acute lung injury. In this report, we are the first to describe a mouse model of S-OIV virus infection with acute lung injury and immune responses that reflect human clinical disease. The clinical efficacy of the antiviral oseltamivir (Tamiflu) administered in the early stages of S-OIV H1N1 infection was confirmed in the mouse model. Moreover, elevated levels of IL-17, Th-17 mediators and IL-17-responsive cytokines were found in serum samples of S-OIV-infected patients in Beijing. IL-17 deficiency or treatment with monoclonal antibodies against IL-17-ameliorated acute lung injury induced by the S-OIV H1N1 virus in mice. These results suggest that IL-17 plays an important role in S-OIV-induced acute lung injury and that monoclonal antibodies against IL-17 could be useful as a potential therapeutic remedy for future S-OIV H1N1 pandemics.

引用

页码：528 / 538

页数：11

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