Lagging strand replication proteins in genome stability and DNA repair

Maintenance of genome integrity is a crucial component in the survival of an organism. As a result, a myriad of pathways function in concert for this purpose. These pathways can be classified into two distinct areas, ones that exist to prevent the accumulation of mutations during replication of the genome and others that repair damage to the genome. This review highlights the role of lagging strand proteins in both of these areas. Topics discussed include lagging strand DNA replication, complexities of replicating repeating sequences, rescue of stalled replication forks, double strand break repair, regulation during the damage response, base excision repair, role of Rad9/Rad1/Hus1 in DNA repair, role of FEN1 in apoptosis, and modifications of lagging strand proteins.