Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD)

被引：139

作者：

Filali, Mohammed ^{[1
,2
]}

Lalonde, Robert ^{[3
]}

Theriault, Peter ^{[1
,2
]}

Julien, Carl

Calon, Frederic

Planel, Emmanuel

机构：

[1] Univ Laval, Dept Mol Med, Quebec City, PQ G1V 4G2, Canada

[2] CHUQ Res Ctr CHUL, Lab Endocrinol & Genom, Quebec City, PQ G1V 4G2, Canada

[3] Univ Rouen, Dept Psychol, EA 4699, F-76821 Mont St Aignan, France

来源：

BEHAVIOURAL BRAIN RESEARCH | 2012年 / 234卷 / 02期

关键词：

Alzheimer models; Transgenic; Amyloid-beta; Tau; Anxiety; Sensorimotor systems; Memory; Open-field; Elevated plus-maze; Object recognition; Left-right discrimination; Rotorod; Hot-plate; SHIRPA; AMYLOID PRECURSOR PROTEIN; APPSWE/PS1 BIGENIC MODEL; INCREASES BDNF LEVELS; A-BETA; MEMORY DEFICITS; MICE; AGE; PATHOLOGY; SHIRPA; BRAIN;

D O I：

10.1016/j.bbr.2012.07.004

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

010107 [宗教学]; 030301 [社会学]; 070906 [古生物学及地层学（含古人类学）];

摘要：

3xTg-AD mutant mice are characterized by parenchymal A beta plaques and neurofibrillary tangles resembling those found in patients with Alzheimer's disease. The mutants were compared with non-transgenic controls in sensorimotor and learning tests. 3xTg-AD mutants were deficient in T-maze reversal, object recognition, and passive avoidance learning. In addition, the mutants showed hypoactivity in two open-field tests, fewer fecal boli in an observation jar, and reduced enclosed arm entries and head-dipping in the elevated plus-maze. On the contrary, the mutants did not differ from controls in pain thresholds, nest-building, and various reflexes determined by the SHIRPA primary screen and were even better on the rotorod test of motor coordination. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：334 / 342

页数：9

共 70 条

[1]

DHA Improves Cognition and Prevents Dysfunction of Entorhinal Cortex Neurons in 3xTg-AD Mice [J].