Enzymatic resolution of (±)-cis- and (±)-trans-1-aminoindan-2-ol and (±)-cis- and (±)-trans-2-aminoindan-1-ol

被引：34

作者：

Luna, A

Maestro, A

Astorga, C

Gotor, V ^{[1
]}

机构：

[1] Univ Oviedo, Fac Quim, Dept Quim Organ & Inorgan, E-33071 Oviedo, Spain

[2] Univ Valladolid, ETS Ingn Ind, Dept Quim Organ, E-47011 Valladolid, Spain

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 10期

关键词：

D O I：

10.1016/S0957-4166(99)00200-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Pseudomonas cepacia lipase (PSL) efficiently catalyses the kinetic resolution of (+/-)-cis- and (+/-)-trans-1-aminoindan-2-ol through the O-acylation reaction of the corresponding N-benzyloxycarbonyl derivative using vinyl acetate as the acyl donor. In a similar way, cis-N-Cbz-2-aminoindan-1-ol is resolved when isopropenyl acetate is used as the acylating agent. The enantioselectivity of the reaction was lower for (+/-)-trans-N-Cbz-2-aminoindan-1-ol due to the different steric requirements for the two conformers of this substrate. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：1969 / 1977

页数：9

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