ProPred: prediction of HLA-DR binding sites

被引:662
作者
Singh, H [1 ]
Raghava, GPS [1 ]
机构
[1] Inst Microbial Technol, Bioinformat Ctr, Chandigarh 160036, India
关键词
D O I
10.1093/bioinformatics/17.12.1236
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
ProPred is a graphical web tool for predicting MHC class 11 binding regions in antigenic protein sequences. The server implement matrix based prediction algorithm, employing amino-acid/position coefficient table deduced from literature. The predicted binders can be visualized either as peaks in graphical interface or as colored residues in HTML interface. This server might be a useful tool in locating the promiscuous binding regions that can bind to several HLA-DR alleles.
引用
收藏
页码:1236 / 1237
页数:2
相关论文
共 5 条
[1]   In vitro and in vivo induction of a Th cell response toward peptides of the melanoma-associated glycoprotein 100 protein selected by the TEPITOPE program [J].
Cochlovius, B ;
Stassar, M ;
Christ, O ;
Raddrizzani, L ;
Hammer, J ;
Mytilineos, I ;
Zöller, M .
JOURNAL OF IMMUNOLOGY, 2000, 165 (08) :4731-4741
[2]   Computers aid vaccine design [J].
Hagmann, M .
SCIENCE, 2000, 290 (5489) :80-82
[3]  
Hammer J, 1997, ADV IMMUNOL, V66, P67, DOI 10.1016/S0065-2776(08)60596-9
[4]   Melanoma cells present a MAGE-3 epitope to CD4+ cytotoxic T cells in association with histocompatibility leukocyte antigen DR11 [J].
Manici, S ;
Sturniolo, T ;
Imro, MA ;
Hammer, J ;
Sinigaglia, F ;
Noppen, C ;
Spagnoli, G ;
Mazzi, B ;
Bellone, M ;
Dellabona, P ;
Protti, MP .
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (05) :871-876
[5]   Generation of tissue-specific and promiscuous HLA ligand databases using DNA microarrays and virtual HLA class II matrices [J].
Sturniolo, T ;
Bono, E ;
Ding, JY ;
Raddrizzani, L ;
Tuereci, O ;
Sahin, U ;
Braxenthaler, M ;
Gallazzi, F ;
Protti, MP ;
Sinigaglia, F ;
Hammer, J .
NATURE BIOTECHNOLOGY, 1999, 17 (06) :555-561