Do the protocadherins Fat and Dachsous link up to determine both planar cell polarity and the dimensions of organs?

被引：54

作者：

Lawrence, Peter A. ^{[1
,2
]}

Struhl, Gary ^{[3
]}

Casal, Jose ^{[1
]}

机构：

[1] Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England

[2] MRC, Mol Biol Lab, Cambridge CB2 0QH, England

[3] Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032 USA

来源：

NATURE CELL BIOLOGY | 2008年 / 10卷 / 12期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1038/ncb1208-1379

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Most, perhaps all cells in epithelial sheets are polarized in the plane of the sheet. This type of polarity, referred to as planar cell polarity (PCP), can be expressed in the orientation of cilia and stereocilia, in oriented outgrowths such as hairs, in the plane of cell division, in directed cell movement and possibly in the orientation of axon extension(1,2). Another popular area in current research is growth: there is an attempt to find systems that fix the shape and size of organs. Although both polarity and growth are subject to overall control by morphogen gradients(3), the mechanisms of this control are almost completely unknown. Here we discuss recent evidence for a 'steepness hypothesis' that links these two apparently disconnected features of animal development.

引用

页码：1379 / 1382

页数：4

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