DNA Gridiron Nanostructures Based on Four-Arm Junctions

被引：225

作者：

Han, Dongran ^{[1
,2
]}

Pal, Suchetan ^{[1
,2
]}

Yang, Yang ^{[1
,2
]}

Jiang, Shuoxing ^{[1
,2
]}

Nangreave, Jeanette ^{[1
,2
]}

Liu, Yan ^{[1
,2
]}

Yan, Hao ^{[1
,2
]}

机构：

[1] Arizona State Univ, Biodesign Inst, Tempe, AZ 85287 USA

[2] Arizona State Univ, Dept Chem & Biochem, Tempe, AZ 85287 USA

来源：

SCIENCE | 2013年 / 339卷 / 6126期

基金：

美国国家科学基金会;

关键词：

FOLDING DNA;

D O I：

10.1126/science.1232252

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Engineering wireframe architectures and scaffolds of increasing complexity is one of the important challenges in nanotechnology. We present a design strategy to create gridiron-like DNA structures. A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons were assembled, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects.

引用

页码：1412 / 1415

页数：4

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