Evaluation of health status and health-related quality of life in a cohort of Italian children following treatment for a primary brain tumor

被引:36
作者
Cardarelli, C [1 ]
Cereda, C [1 ]
Masiero, L [1 ]
Viscardi, E [1 ]
Faggin, R [1 ]
Laverda, A [1 ]
Bisogno, G [1 ]
Perilongo, G [1 ]
机构
[1] Univ Padua, Dept Pediat, Div Hematol Oncol, Pediat Neuro Oncol Program, I-35128 Padua, Italy
关键词
brain tumors; children; health-related quality of life; health status;
D O I
10.1002/pbc.20480
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background. This study is a pilot experience aiming to investigate the compliance of an institutional cohort of Italian children treated for a malignant disease and their families in completing the health utilities index2, (HUI2) and the effectiveness of this measured ill terms of their health Status (HS) and health-related quality of life (HRQL). It specifically, it aimed to compare the HS and the HRQL, as expressed by the HUI2 global utility score, in cohorts of patients who had brain tumors, extra-cerebral solid tumors, or leukemia/lymphoma. Procedure. Fifty Survivors of brain tumors, between 8 and 30 years at the time of the assessment ("self") and/or their parents ("proxy"), attending the Pediatric Oncology Out Patient clinic of Padua, Italy, completed the HUI2 questionnaire. Eighty-nine children with acute leukemia/lyrnphoma and 74 with extra-cerebral solid tumors and/or their parents were also assessed. Results. The mean "self" and "proxy" HUI2 global utility scores in the brain tumor patients were 0.87 and 0.84, respectively, while in the cohorts of children with other solid tumors and leukemia/lymphoma, there were 0.94, 0.91, 0.96, and 0.92, respectively. The differences between the HUI2 global utility scores in the "self" and "proxy" assessment within each cohort of children were not statistically significant. In decreasing order of frequency, the attributes affected most commonly were: "emotion," " pain," "sensation," and "cognition" both by "self" and "proxy" assessment. Conclusions. In this Italian population of childhood cancer survivors the HUI2 questionnaire proved to be a user-friendly tool, which provided information regarding HS and HRQL. A larger cohort of cancer children is needed to confirm the efficacy of the HUI2 questionnaire in distinguishing groups of children on this basis by disease category.
引用
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页码:637 / 644
页数:8
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