Modulation of channel function by polyamines

被引：137

作者：

Johnson, TD

机构：

[1] Department of Anesthesiolagy, Houston, TX 77030, One Baylor Plaza

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1996年 / 17卷 / 01期

关键词：

D O I：

10.1016/0165-6147(96)81566-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Polyamines are found in every cell of the body and the intricate enzymatic reactions responsible for their metabolism and transport in mammalian cells are now well understood. Despite intense efforts, elucidation of the role of polyamines has suffered in that little information of physiological relevance has surfaced. Recently, recombinant receptor techniques and increased availability of polyamine analogues have revealed, as discussed here by David Johnson, modulation of NMDA receptors by polyamines by reversal of tonic proton inhibition, and a function for these compounds as 'intrinsic rectifier factors' for K+ channels.

引用

收藏

页码：22 / 27

页数：6

相关论文

共 52 条

[1]

BONEV A, 1994, BIOPHYS J, V66, pA327

[2] RELEASE OF SPERMIDINE FROM THE RAT CORTEX FOLLOWING PERMANENT MIDDLE CEREBRAL-ARTERY OCCLUSION [J].

CARTER, C ;

POIGNET, H ;

CARBONI, S ;

FAGE, D ;

VOLTZ, C ;

SCATTON, B .

FUNDAMENTAL & CLINICAL PHARMACOLOGY, 1995, 9 (02) :129-140

[3]

COLLINGRIDGE GL, 1989, PHARMACOL REV, V41, P143

[4] TRANSGLUTAMINASE-CATALYZED INCORPORATION OF POLYAMINES INTO PHOSPHOLIPASE-A2 [J].

CORDELLAMIELE, E ;

MIELE, L ;

BENINATI, S ;

MUKHERJEE, AB .

JOURNAL OF BIOCHEMISTRY, 1993, 113 (02) :164-173

[5] EXCITATORY AMINO-ACID RECEPTORS IN EPILEPSY [J].

DINGLEDINE, R ;

MCBAIN, CJ ;

MCNAMARA, JO .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (08) :334-338

[6] CLONING OF AN APPARENT SPLICE VARIANT OF THE RAT N-METHYL-D-ASPARTATE RECEPTOR NMDAR1 WITH ALTERED SENSITIVITY TO POLYAMINES AND ACTIVATORS OF PROTEIN-KINASE-C [J].

DURAND, GM ;

GREGOR, P ;

ZHENG, X ;

BENNETT, MVL ;

UHL, GR ;

ZUKIN, RS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (19) :9359-9363

[7] SPLICE VARIANTS OF THE N-METHYL-D-ASPARTATE RECEPTOR NR1 IDENTIFY DOMAINS INVOLVED IN REGULATION BY POLYAMINES AND PROTEIN-KINASE-C [J].

DURAND, GM ;

BENNETT, MVL ;

ZUKIN, RS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (14) :6731-6735

[8] INWARD RECTIFICATION IN SUBMUCOSAL ARTERIOLES OF GUINEA-PIG ILEUM [J].

EDWARDS, FR ;

HIRST, GDS .

JOURNAL OF PHYSIOLOGY-LONDON, 1988, 404 :437-454

[9] STRONG VOLTAGE-DEPENDENT INWARD RECTIFICATION OF INWARD RECTIFIER K+ CHANNELS IS CAUSED BY INTRACELLULAR SPERMINE [J].

FAKLER, B ;

BRANDLE, U ;

GLOWATZKI, E ;

WEIDEMANN, S ;

ZENNER, HP ;

RUPPERSBERG, JP .

CELL, 1995, 80 (01) :149-154

[10] SPERMINE AND SPERMIDINE AS GATING MOLECULES FOR INWARD RECTIFIER K+ CHANNELS [J].

FICKER, E ;

TAGLIALATELA, M ;

WIBLE, BA ;

HENLEY, CM ;

BROWN, AM .

SCIENCE, 1994, 266 (5187) :1068-1072

← 1 2 3 4 5 6 →