Behavioral Sequence Analysis Reveals a Novel Role for β2*Nicotinic Receptors in Exploration

被引:33
作者
Maubourguet, Nicolas [1 ,2 ]
Lesne, Annick [3 ]
Changeux, Jean-Pierre [1 ,2 ]
Maskos, Uwe [1 ,2 ]
Faure, Philippe [1 ,2 ]
机构
[1] Inst Pasteur, Unite Neurobiol Integrat Syst Cholinerg, Paris, France
[2] CNRS, URA 2182, Paris, France
[3] Inst Hautes Etud Sci, F-91440 Bures Sur Yvette, France
关键词
D O I
10.1371/journal.pcbi.1000229
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Nicotinic acetylcholine receptors (nAChRs) are widely expressed throughout the central nervous system and modulate neuronal function in most mammalian brain structures. The contribution of defined nAChR subunits to a specific behavior is thus difficult to assess. Mice deleted for beta 2-containing nAChRs (beta 2-/-) have been shown to be hyperactive in an open-field paradigm, without determining the origin of this hyperactivity. We here develop a quantitative description of mouse behavior in the open field based upon first order Markov and variable length Markov chain analysis focusing on the time-organized sequence that behaviors are composed of. This description reveals that this hyperactivity is the consequence of the absence of specific inactive states or "stops". These stops are associated with a scanning of the environment in wildtype mice (WT), and they affect the way that animals organize their sequence of behaviors when compared with stops without scanning. They characterize a specific "decision moment" that is reduced in beta 2-/- mutant mice, suggesting an important role of beta 2-nAChRs in the strategy used by animals to explore an environment and collect information in order to organize their behavior. This integrated analysis of the displacement of an animal in a simple environment offers new insights, specifically into the contribution of nAChRs to higher brain functions and more generally into the principles that organize sequences of behaviors in animals.
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页数:12
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