14-3-3 proteins as potential oncogenes

被引：212

作者：

Tzivion, Guri

Gupta, Vinita Singh

Kaplun, Ludmila

Balan, Vitaly

机构：

[1] Wayne State Univ, Karmanos Canc Inst, Detroit, MI 48201 USA

[2] Wayne State Univ, Dept Pathol, Detroit, MI 48201 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2006年 / 16卷 / 03期

关键词：

14-3-3; raf; cell-cycle; mitogenesis; cancer;

D O I：

10.1016/j.semcancer.2006.03.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

14-3-3 proteins are a family of highly conserved cellular proteins that play key roles in the regulation of central physiological pathways. More than 200 14-3-3 target proteins have been identified, including proteins involved in mitogenic and cell survival signaling, cell cycle control and apoptotic cell death. Importantly, the involvement of 14-3-3 proteins in the regulation of various oncogenes and tumor suppressor genes points to a potential role in human cancer. The present review summarizes current findings implicating a 14-3-3 role in cancer while discussing potential mechanisms and points of action of 14-3-3 during cancer development and progression. (c) 2006 Elsevier Ltd. All rights reserved.

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收藏

页码：203 / 213

页数：11

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