Thrombin Inhibition by Argatroban Ameliorates Early Brain Injury and Improves Neurological Outcomes After Experimental Subarachnoid Hemorrhage in Rats

被引：76

作者：

Sugawara, Takashi ^{[2
,4
]}

Jadhav, Vikram ^{[2
]}

Ayer, Robert ^{[2
]}

Chen, Wanqiu ^{[2
]}

Suzuki, Hidenori ^{[2
]}

Zhan, John H. ^{[1
,2
,3
]}

机构：

[1] Loma Linda Univ, Med Ctr, Dept Neurosurg, Loma Linda, CA 92354 USA

[2] Loma Linda Univ, Dept Physiol, Loma Linda, CA 92354 USA

[3] Loma Linda Univ, Dept Anesthesiol, Loma Linda, CA 92354 USA

[4] Tokyo Med & Dent Univ, Grad Sch, Dept Brain Med Sci, Div Cognit & Behav Med,Sect Neurosurg, Tokyo, Japan

来源：

STROKE | 2009年 / 40卷 / 04期

关键词：

argatroban; brain edema; early brain injury; subarachnoid hemorrhage; thrombin; INTRACEREBRAL HEMORRHAGE; MODEL; MECHANISMS; APOPTOSIS; VASOSPASM; EDEMA;

D O I：

10.1161/STROKEAHA.108.531699

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-We investigated the role of thrombin in early brain injury after subarachnoid hemorrhage (SAH). Methods-The standard intravascular perforation model was used to produce experimental SAH in Sprague Dawley rats. Low-dose (0.3 mg/h) and high-dose (0.9 mg/h) argatroban, a direct thrombin inhibitor, were evaluated for effects on brain edema, blood-brain barrier (BBB) disruption, apoptotic cell death, inflammatory marker, and neurological outcomes after SAH. Results-Both doses of argatroban attenuated BBB disruption; however, only high-dose was effective in lowering edema in all brain regions, reducing cell death, and inflammatory marker expression, and improving neurological outcomes. Conclusions-Thrombin inhibition by argatroban improves neurological outcomes and provides neuroprotection against acute events after SAH such as BBB disruption, brain edema, and cell death. (Stroke. 2009;40:1530-1532.)

引用

页码：1530 / 1532

页数：3

共 15 条

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